diflunisal (dolobid) Report issue

Small molecule Approved FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. It was developed by Merck Sharp & Dohme in 1971 after showing promise in a research project studying more potent chemical analogs of aspirin. Diflunisal is an aspirin-like nonsteroidal anti-inflammatory drug that inhibits cyclooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis.In animals, prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain. Since prostaglandins are known to be among the mediators of pain and inflammation, the mode of action of diflunisal may be due to a decrease of prostaglandins in peripheral tissues.   NCATS

Chemistry

  • SMILES: OC(=O)C1=C(O)C=CC(=C1)C2=CC=C(F)C=C2F
  • InChIKey: HUPFGZXOMWLGNK-UHFFFAOYSA-N
  • Mol. Mass: 250.1976
  • ALogP: 3.04
  • ChEMBL Molecule:
    diflunisal  
More Chemistry

Pharmacology

Drug Pricing (per unit)

United States

$1.0050 - $1.2232
More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Alternative names

2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid | 2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acid | 5-(2,4-difluorophenyl)salicylic acid | difludol | diflunisal | diflunisalum | difluorophenylsalicylic acid | diflusinal | dolobid | dolobid 500 | fluniget | fluodonil | mk-647

Organizations (16)

Research & Development (6)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (10)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (8)

Approved Indications (3)


 

Arthritis, Rheumatoid (approved 1982)

Osteoarthritis (approved 1982)

Pain (approved 1982)

Experimental Indications - Clinical Trial Phases 1-4 (5)


 

Amyloid Neuropathies, Familial (Phase 2/Phase 3)

Amyloidosis, Familial (Phase 2/Phase 3)

Diabetes Mellitus, Type 2 (Phase 2)

Healthy Volunteers (Phase 1)

HIV Infections (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 4
  • # of Trial Organizations: 6

Trials by Phase

Trial Phase Start Date Organizations Indications

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