diethylstilbestrol (Fosfestrol) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem

Active Ingredient History

NOW
  • Now
Diethylstilbestrol (DES), also known as stilbestrol or stilboestrol, is a nonsteroidal estrogen medication, which is presently rarely used. In the past, it was widely used for a variety of indications, including pregnancy support for those with a history of recurrent miscarriage, hormone therapy for menopausal symptoms and estrogen deficiency, treatment of prostate cancer and breast cancer, and other uses. By 2007, it was only used in the treatment of prostate cancer and breast cancer. In 2011, Hoover and colleagues reported on adverse health outcomes linked to DES including infertility, miscarriage, ectopic pregnancy, preeclampsia, preterm birth, stillbirth, infant death, menopause prior to age 45, breast cancer, cervical cancer, and vaginal cancer. While most commonly taken by mouth, DES was available for use by other routes as well, for instance, vaginal, topical, and by injection.   Wikipedia

Chemistry

  • SMILES: CC\C(=C(\CC)/c1ccc(O)cc1)\c2ccc(O)cc2
  • InChIKey: RGLYKWWBQGJZGM-ISLYRVAYSA-N
  • Mol. Mass: 268.36
  • ALogP: 4.83
  • ChEMBL Molecule:
    diethylstilbestrol  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Oral, Parenteral, Topical
  • Pro Drug: No

Alternative names

4,4'-dihydroxy-alpha,beta-diethylstilbene | 4,4'-dihydroxy-α,β-diethylstilbene | agostilben | alpha,alpha'-diethyl-(e)-4,4'-stilbenediol | antigestil | apstil | cyren a | des | diethylstilbestrol | diethylstilbestrolum | dietilestilbestrol | distilbene | (e)-3,4-bis(4-hydroxyphenyl)-3-hexene | (e)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol | estrobene | estrogenine | estromenin | fonatol | new-estranol 1 | palestrol | stilbestroform | stilbestrol | stilbetin | stilboesterol | stilboestrol | synestrin | synthestrin | tampovagan | trans-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol | trans-diethylstilbesterol | trans-diethylstilbestrol | trans-diethylstilboesterol | α,α'-diethyl-(e)-4,4'-stilbenediol

Organizations (6)

Research & Development (3)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (3)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (2)

Approved Indications (1)


 

Abortion, Spontaneous (approved 1941)

Experimental Indications - Clinical Trial Phases 1-4 (1)


 

Prostatic Neoplasms (Phase 3)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 2
  • # of Trial Organizations: 3

Trials by Phase

Trial Phase Start Date Organizations Indications

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