Active Ingredient History
Cannabidiol is the major nonpsychoactive ingredient in cannabis. Cannabidiol demonstrates a range of effects that may be therapeutically useful, including anti-seizure, antioxidant, neuroprotective, anti-inflammatory, analgesic, anti-tumor, anti-psychotic, and anti-anxiety properties. Exact mechanism of action of cannabidiol is not known, but may include effects on the orphan G-protein-coupled receptor GPR55; the transient receptor potential of vanilloid type-1 channel; the 5-HT1a receptor; and the α3 glycine receptors. GW Pharmaceuticals successfully developed the world’s first prescription medicine derived from the cannabis plant, Sativex® (buccal spray containing delta-9-tetrahydrocannabinol and cannabidiol) now approved in over 29 countries outside of the United States for the treatment of spasticity due to Multiple Sclerosis. GW Pharmaceuticals is developing Epidiolex® (a liquid formulation of pure plant-derived cannabidiol) for certain rare and severe early-onset, drug-resistant epilepsy syndromes. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
22q11 Deletion Syndrome (Phase 1/Phase 2)
Acne Vulgaris (Phase 2)
Acute Pain (Phase 3)
Affect (Early Phase 1)
Affective Symptoms (Phase 2)
Aging (Phase 1)
Agoraphobia (Phase 3)
Alcohol-Induced Disorders (Phase 2)
Alcoholism (Phase 2/Phase 3)
Alcohol Withdrawal Delirium (Early Phase 1)
Alzheimer Disease (Phase 2)
Amphetamine-Related Disorders (Phase 2)
Amyotrophic Lateral Sclerosis (Phase 4)
Analgesics, Opioid (Phase 4)
Anger (Phase 2/Phase 3)
Ankle Fractures (Phase 4)
Anorexia (Phase 1)
Anorexia Nervosa (Early Phase 1)
Anxiety (Phase 4)
Anxiety Disorders (Phase 3)
Appetite (Phase 3)
Appetitive Behavior (Phase 1)
Arterial Occlusive Diseases (Phase 2/Phase 3)
Arthralgia (Phase 4)
Arthritis, Psoriatic (Phase 2)
Arthritis, Rheumatoid (Phase 2)
Arthroplasty, Replacement, Knee (Phase 2/Phase 3)
Autism Spectrum Disorder (Phase 2/Phase 3)
Autistic Disorder (Phase 2/Phase 3)
Automobile Driving (Early Phase 1)
Back Pain (Phase 3)
Behavior (Phase 2)
Behavior, Addictive (Phase 2)
Biological Availability (Phase 1)
Bipolar Disorder (Phase 3)
Blepharospasm (Phase 2/Phase 3)
Body Mass Index (Phase 1)
Bone Diseases, Metabolic (Phase 1)
Brain Injuries, Traumatic (Phase 3)
Brain Neoplasms (Phase 2)
Breakthrough Pain (Phase 2)
Breast Neoplasms (Phase 3)
Bronchiectasis (Phase 2)
Bruxism (Phase 2/Phase 3)
Burnout, Psychological (Phase 2/Phase 3)
Cachexia (Phase 3)
Cancer Pain (Phase 3)
Cannabidiol (Phase 4)
Cannabinoids (Early Phase 1)
Cannabis (Phase 4)
Carcinoma, Hepatocellular (Phase 1)
Carcinoma, Non-Small-Cell Lung (Phase 1)
Carcinoma, Renal Cell (Phase 1)
Cardiovascular Diseases (Phase 2/Phase 3)
Carpal Tunnel Syndrome (Phase 2)
Chronic Pain (Phase 4)
Chronic Periodontitis (Phase 1/Phase 2)
Chronic Urticaria (Phase 2)
Cocaine-Related Disorders (Phase 2)
Cognition Disorders (Phase 2)
Cognitive Dysfunction (Phase 4)
Colitis, Ulcerative (Phase 2)
Colonic Neoplasms (Phase 1/Phase 2)
Colorectal Neoplasms (Phase 2)
Conscious Sedation (Early Phase 1)
Contraception (Phase 4)
COVID-19 (Phase 2/Phase 3)
Crohn Disease (Phase 2/Phase 3)
Cystitis, Interstitial (Phase 1)
Dementia (Phase 2)
Depression (Phase 2/Phase 3)
Depressive Disorder, Major (Phase 2)
Depressive Disorder, Treatment-Resistant (Phase 4)
Dermatitis, Atopic (Phase 3)
Diabetes Mellitus, Type 2 (Phase 2)
Diabetic Neuropathies (Phase 2)
Diagnosis, Dual (Psychiatry) (Phase 2)
Dialysis (Phase 1)
Diet Therapy (Early Phase 1)
Dronabinol (Phase 2)
Drug Evaluation (Phase 4)
Drug Interactions (Phase 4)
Drug Resistant Epilepsy (Phase 2)
Drugs, Investigational (Phase 1)
Dyslipidemias (Phase 2)
Dysmenorrhea (Phase 2)
Dyspepsia (Phase 2)
Electromyography (Phase 2/Phase 3)
Emergency Service, Hospital (Phase 1)
Endometriosis (Phase 3)
Epidermolysis Bullosa (Phase 2/Phase 3)
Epidermolysis Bullosa Dystrophica (Phase 2)
Epidermolysis Bullosa, Junctional (Phase 2)
Epidermolysis Bullosa Simplex (Phase 2)
Epilepsies, Myoclonic (Phase 4)
Epilepsy (Phase 4)
Epilepsy, Absence (Phase 2)
Essential Tremor (Phase 1/Phase 2)
Facial Pain (Phase 2/Phase 3)
Fatigue (Phase 2)
Fatty Liver (Phase 2)
Fear (Phase 2)
Fibromyalgia (Phase 3)
Fractures, Bone (Phase 4)
Fragile X Syndrome (Phase 3)
Gallbladder Neoplasms (Phase 1/Phase 2)
Gastroparesis (Phase 2)
Glioblastoma (Phase 2)
Graft vs Host Disease (Phase 2)
Hallux Rigidus (Phase 2/Phase 3)
Hallux Valgus (Phase 2/Phase 3)
Headache (Phase 2/Phase 3)
Headache Disorders, Secondary (Phase 4)
Healthy Volunteers (Phase 1)
Heart Disease Risk Factors (Phase 2/Phase 3)
Heart Diseases (Phase 2)
Heart Failure (Phase 1)
Hepatitis, Autoimmune (Phase 2)
Heroin Dependence (Phase 2)
HIV (Phase 2)
HIV Infections (Phase 2)
HIV Seropositivity (Phase 2)
Hoarding Disorder (Phase 2)
Huntington Disease (Phase 2)
Hyperopia (Phase 2)
Hypertension (Phase 1)
Inflammation (Phase 4)
Inflammatory Bowel Diseases (Phase 2/Phase 3)
Intellectual Disability (Phase 2)
Intestinal Neoplasms (Phase 1)
Kidney Diseases (Phase 1)
Lennox Gastaut Syndrome (Phase 4)
Liver Neoplasms (Phase 1/Phase 2)
Low Back Pain (Phase 4)
Malnutrition (Phase 3)
Marijuana Smoking (Phase 2)
Memory (Phase 2)
Menstruation Disturbances (Phase 2)
Mental Disorders (Phase 2)
Mental Health (Phase 3)
Mesothelioma (Phase 1)
Microbiota (Phase 2)
Migraine Disorders (Phase 4)
Mood Disorders (Phase 2)
Morbidity (Phase 2)
Mortality (Phase 2)
Motor Neuron Disease (Phase 4)
Multiple Myeloma (Phase 1/Phase 2)
Multiple Sclerosis (Phase 2)
Musculoskeletal Pain (Phase 2/Phase 3)
Myalgia (Phase 2/Phase 3)
Myofascial Pain Syndromes (Phase 2/Phase 3)
Myopia (Phase 2)
Nausea (Phase 2)
Neck Pain (Phase 3)
Neoplasms (Phase 3)
Neural Analyzers (Early Phase 1)
Neuralgia (Phase 2)
Neuroinflammatory Diseases (Phase 2)
Obsessive-Compulsive Disorder (Phase 2)
Opioid-Related Disorders (Phase 2)
Osteoarthritis (Phase 4)
Osteoarthritis, Knee (Phase 4)
Ovarian Neoplasms (Phase 2)
Pain (Phase 3)
Pain, Postoperative (Phase 4)
Palliative Medicine (Phase 2)
Pancreatic Neoplasms (Phase 2)
Panic (Phase 2)
Panic Disorder (Phase 3)
Parkinson Disease (Phase 2)
Pelvic Pain (Phase 3)
Pericarditis (Phase 2)
Pharmacokinetics (Phase 1)
Pharmacology (Phase 1)
Phobia, Social (Phase 4)
Photorefractive Keratectomy (Phase 2)
Postoperative Nausea and Vomiting (Early Phase 1)
Prader-Willi Syndrome (Phase 3)
Prostatic Neoplasms (Phase 1)
Pruritus (Phase 2/Phase 3)
Psychological Distress (Phase 2/Phase 3)
Psychomotor Agitation (Early Phase 1)
Psychotic Disorders (Phase 2)
Quality of Life (Phase 2)
Radiculopathy (Phase 1/Phase 2)
Rare Diseases (Phase 2)
Rectal Neoplasms (Phase 1/Phase 2)
Renal Insufficiency, Chronic (Phase 1)
Rett Syndrome (Phase 3)
Safety (Phase 1)
Schizophrenia (Phase 2)
Scleroderma, Systemic (Phase 3)
Sclerosis (Phase 3)
Seizures (Phase 3)
Skin Absorption (Phase 1)
Sleep (Phase 2)
Sleep Disorders, Intrinsic (Phase 2/Phase 3)
Sleep Wake Disorders (Phase 2)
Spasms, Infantile (Phase 3)
Spinal Cord Injuries (Phase 2)
Sprains and Strains (Phase 2)
Stress Disorders, Post-Traumatic (Phase 2/Phase 3)
Sturge-Weber Syndrome (Phase 2)
Substance-Related Disorders (Phase 2/Phase 3)
Substance Withdrawal Syndrome (Phase 2)
Temporomandibular Joint Disorders (Phase 2/Phase 3)
Tension-Type Headache (Phase 2/Phase 3)
Tobacco Smoking (Phase 1)
Tobacco Use (Phase 1)
Tobacco Use Cessation (Phase 1)
Tobacco Use Disorder (Phase 1)
Toothache (Phase 1/Phase 2)
Tourette Syndrome (Phase 2)
Transplants (Phase 1)
Trichotillomania (Phase 2)
Triple Negative Breast Neoplasms (Phase 1)
Tuberous Sclerosis (Phase 4)
Urinary Calculi (Phase 2/Phase 3)
Uterine Neoplasms (Phase 2)
Vomiting (Phase 1)
Wounds and Injuries (Early Phase 1)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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