Active Ingredient History
Defibrotide, sold under the brand name Defitelio, is a mixture of single-stranded oligonucleotides that is purified from the intestinal mucosa of pigs. It is used to treat veno-occlusive disease of the liver of people having had a bone marrow transplant, with different limitations in the US and the European Union. It works by protecting the cells lining blood vessels in the liver and preventing blood clotting; the way it does this is not well understood. Wikipedia
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Acute Chest Syndrome (Phase 2)
Anemia, Sickle Cell (Phase 2)
Arterial Occlusive Diseases (Phase 3)
Bone Marrow Transplantation (Phase 2)
COVID-19 (Phase 2)
Endotoxemia (Phase 4)
Graft vs Host Disease (Phase 2)
Healthy Volunteers (Phase 4)
Hepatic Veno-Occlusive Disease (Phase 3)
Lymphoma, Large-Cell, Immunoblastic (Phase 2)
Mucocutaneous Lymph Node Syndrome (Phase 2)
Multiple Myeloma (Phase 1/Phase 2)
Neuroblastoma (Phase 2)
Neurotoxicity Syndromes (Phase 2)
Respiratory Distress Syndrome (Phase 1)
Thrombosis (Phase 2)
Thrombotic Microangiopathies (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
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