Active Ingredient History
Dabrafenib is a selective, orally bioavailable inhibitor of Mutant BRAF protein kinase with potential antineoplastic activity. Dabrafenib inhibits BRAF kinases with in vitro IC50 values of 0.65, 0.5, and 1.84 nM for BRAF V600E, BRAF V600K, and BRAF V600D enzymes, respectively. Dabrafenib also inhibits wild-type BRAF and CRAF kinases with IC50 values of 3.2 and 5.0 nM. BRAF belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. Mutations in BRAF are associated with increased growth and proliferation of cancer cells. By inhibiting BRAF kinase dabrafenib negatively regulates the proliferation of tumor cells which contain a mutated BRAF gene. Dabrafenib (in combination with trametinib or alone) is indicated for the treatment of unresectable or metastatic melanoma with BRAF V600E mutation NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Adenoma, Oxyphilic (Phase 2)
Ameloblastoma (Phase 2)
Astrocytoma (Phase 4)
Bile Duct Neoplasms (Phase 2)
Brain Neoplasms (Phase 2)
Breast Neoplasms (Phase 2)
Carcinoma, Non-Small-Cell Lung (Phase 4)
Colonic Neoplasms (Phase 2)
Colorectal Neoplasms (Phase 2)
Craniopharyngioma (Phase 2)
Dermatology (Phase 2)
Endometrial Neoplasms (Phase 2)
Erdheim-Chester Disease (Phase 2)
Esophageal Neoplasms (Phase 2)
Ganglioglioma (Phase 4)
Ganglioneuroma (Phase 4)
Glioblastoma (Phase 4)
Glioma (Phase 4)
Kidney Failure, Chronic (Phase 1)
Kidney Neoplasms (Phase 2)
Liver Diseases (Phase 1)
Liver Neoplasms (Phase 2)
Lung Neoplasms (Phase 2)
Lymphoma (Phase 2)
Melanoma (Phase 4)
Multiple Myeloma (Phase 2)
Mutation (Phase 2)
Neoplasm Metastasis (Phase 2)
Neoplasms ()
Neurocytoma (Phase 4)
Neurofibromatosis 1 (Phase 4)
Oligodendroglioma (Phase 4)
Ovarian Neoplasms (Phase 2)
Pancreatic Neoplasms (Phase 2)
Paraganglioma (Phase 4)
Prostatic Neoplasms (Phase 2)
Proto-Oncogene Proteins B-raf (Phase 2)
Renal Insufficiency (Phase 1)
Sarcoma (Phase 3)
Skin Neoplasms (Phase 2)
Squamous Cell Carcinoma of Head and Neck (Phase 2)
Stomach Neoplasms (Phase 2)
Thyroid Cancer, Papillary (Phase 2)
Thyroid Carcinoma, Anaplastic (Phase 2)
Thyroid Neoplasms (Phase 3)
Urinary Bladder Neoplasms (Phase 2)
Uterine Cervical Neoplasms (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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