cyclizine lactate (marezine) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Cyclizine (cyclizine hydrochloride, Valoid®) is a histamine H1 antagonist of the piperazine class which is characterised by a low incidence of drowsiness. It possesses anticholinergic and antiemetic properties. The exact mechanism by which cyclizin (cyclizine hydrochloride, Valoid®) can prevent or suppress both nausea and vomiting from various causes is unknown. It increases lower oesophageal sphincter tone and reduces the sensitivity of the labyrinthine apparatus. It may inhibit the part of the midbrain known collectively as the emetic centre.   NCATS

Chemistry

More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Parenteral
  • Pro Drug: No

Alternative names

1-benzhydryl-4-methylpiperazin | (+-)-1-diphenylmethyl-4-methylpiperazine | (±)-1-diphenylmethyl-4-methylpiperazine | 1-(diphenylmethyl)-4-methylpiperazine | ciclizina | cyclizine | cyclizine hcl | cyclizine lactate | cyclizinum | marezine | marzine | nautazine | (n-benzhydryl)(n'-methyl)diethylenediamine | n-benzhydryl-n'-methylpiperazine | n-methyl-n'-benzhydrylpiperazine

Organizations (5)

Research & Development (4)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (5)

Approved Indications (3)


 

Motion Sickness (approved 2005)

Postoperative Nausea and Vomiting (approved 2005)

Vomiting (approved 2005)

Experimental Indications - Clinical Trial Phases 1-4 (2)


 

Malaria (Phase 1/Phase 2)

Neoplasms (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 4
  • # of Trial Organizations: 4

Trials by Phase

Trial Phase Start Date Organizations Indications

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