API | quizartinib

quizartinib (VANFLYTA) Report issue

Small molecule Orphan Drug ^FDA Approved ^FDA Fast Track ^FDA Priority Review ^FDA

AACT ChEMBL DrugBank MeSH PubChem

Active Ingredient History

NOW

Quizartinib, sold under the brand name Vanflyta, is an anti-cancer medication used for the treatment of acute myeloid leukemia. ^Wikipedia

Chemistry

SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1
InChIKey: CVWXJKQAOSCOAB-UHFFFAOYSA-N
Mol. Mass: 560.68
ALogP: 5.86 Partition coefficient
ChEMBL Molecules:

quizartinib

quizartinib dihydrochloride

More Chemistry

Pharmacology

Mechanisms of Action:
- Macrophage colony-stimulating factor 1 receptor (Homo sapiens) ^UniProt
- Platelet-derived growth factor receptor alpha (Homo sapiens) ^UniProt
- Platelet-derived growth factor receptor beta (Homo sapiens) ^UniProt
- Mast/stem cell growth factor receptor Kit (Homo sapiens) ^UniProt
- Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens) ^UniProt
- Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: Yes
Availability: Prescription Only
Delivery Methods: Oral
Pro Drug: No

ac010220 | ac010220.2hcl | ac220 | ac-220 | ac220 compound | asp-2689 | quizartinib | quizartinib dihydrochloride

Organizations (19)

Research & Development (19)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (1)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (15)

Approved Indications (1)

Leukemia, Myeloid, Acute

Experimental Indications - Clinical Trial Phases 1-4 (15)

Biomarkers (Phase 1/Phase 2)

Bone Marrow Cells (Phase 2)

Drug Interactions (Early Phase 1)

Drugs, Investigational (Early Phase 1)

Healthy Volunteers (Phase 1)

Leukemia (Phase 3)

Leukemia, Myeloid, Acute (Phase 3)

Leukemia, Myelomonocytic, Chronic (Phase 1/Phase 2)

Liver Diseases (Phase 1)

Mutation (Phase 1/Phase 2)

Myelodysplastic Syndromes (Phase 3)

Myeloproliferative Disorders (Phase 1/Phase 2)

Neoplasms (Phase 1)

Pharmacokinetics (Early Phase 1)

Precursor Cell Lymphoblastic Leukemia-Lymphoma (Phase 1)

Overview

Highest Phase: Phase 3
# of Trials: 34
# of Trial Organizations: 19

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

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