Active Ingredient History

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Clodronic acid (INN) or clodronate disodium (USAN) is a first generation (non-nitrogenous) bisphosphonate. It is an anti-osteoporotic drug approved for the prevention and treatment of osteoporosis in post-menopausal women and men to reduce vertebral fractures, hyperparathyroidism, hypercalcemia in malignancy, multiple myeloma and fracture related pain because of its potent anti-inflammatory and analgesic effects shown as a reduction in inflammatory markers like IL-1β, IL-6, and TNF-α.   Wikipedia

  • SMILES: [Na+].[Na+].OP(=O)([O-])C(Cl)(Cl)P(=O)(O)[O-]
  • InChIKey: HJKBJIYDJLVSAO-UHFFFAOYSA-L
  • Mol. Mass: 288.86
  • ALogP: 0.43
  • ChEMBL Molecule:
More Chemistry
177501 | bonefos | clodronate disodium | disodium clodronate | zk-00091106

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