citric acid Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem

Active Ingredient History

NOW
  • Now
Potassium citrate is indicated for the management of renal tubular acidosis with calcium stones, hypocitraturic calcium oxalate nephrolithiasis of any etiology, uric acid lithiasis with or without calcium stones. WhenPotassium citrate is given orally, the metabolism of absorbed citrate produces an alkaline load. The induced alkaline load in turn increases urinary pH and raises urinary citrate by augmenting citrate clearance without measurably altering ultrafilterable serum citrate. Thus, potassium citrate therapy appears to increase urinary citrate principally by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate. Potassium citrate is used as a food additive (E 332) to regulate acidity.   NCATS

Chemistry

More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral, Parenteral
  • Pro Drug: No

Combination drugs

( urea-13c (PyloPlus), citric acid )
|
( magnesium oxide, citric acid, sodium carbonate - other name: urologic g )
|
( lactic acid, citric acid, potassium bitartrate )
|
( magnesium oxide, sodium picosulfate (Preopik), citric acid - other name: clenpiq )
|
( magnesium carbonate, gluconolactone, citric acid )

Alternative names

2-hydroxytricarballylic acid | 3-carboxy-3-hydroxypentane-1,5-dioic acid | anhydrous citric acid | citrasate | citrate | citric acid | citric acid, anhydrous | citric acid monohydrate | citronensäure | e330 | urologic g

Organizations (72)

Research & Development (63)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (11)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (29)

Approved Indications (2)


 

Acidosis, Renal Tubular (approved 1985)

Nephrolithiasis (approved 1985)

Experimental Indications - Clinical Trial Phases 1-4 (27)


 

Acute Kidney Injury (Phase 4)

Acute-On-Chronic Liver Failure (Phase 2)

Alkalosis (Phase 3)

Ascites (Phase 2)

Catheter-Related Infections (Phase 3)

Chlamydia (Phase 2)

Colonoscopy (Phase 4)

Colorectal Neoplasms (Phase 4)

Contraception (Phase 3)

Corneal Diseases (Phase 4)

Cystitis, Interstitial (Phase 2)

Dental Pulp (Phase 4)

General Surgery (Phase 4)

Headache (Phase 2/Phase 3)

Healthy Volunteers (Phase 2)

Intestine, Large (Phase 4)

Iron Deficiencies (Phase 2)

Kidney Diseases (Phase 4)

Kidney Failure, Chronic (Phase 4)

Pelvic Pain (Phase 2)

Periodontal Diseases (Phase 4)

Quality of Life (Phase 4)

Renal Dialysis (Phase 4)

Sjogren's Syndrome (Phase 4)

Urinary Bladder Diseases (Phase 2)

Wounds and Injuries (Phase 4)

Xerostomia (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 49
  • # of Trial Organizations: 63

Trials by Phase

Trial Phase Start Date Organizations Indications

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