Active Ingredient History
Ceftobiprole, sold under the brand name Zevtera among others, is a fifth-generation cephalosporin antibacterial used for the treatment of hospital-acquired pneumonia and community-acquired pneumonia. It is marketed by Basilea Pharmaceutica under the brand names Zevtera and Mabelio. Like other cephalosporins, ceftobiprole exerts its antibacterial activity by binding to important penicillin-binding proteins and inhibiting their transpeptidase activity which is essential for the synthesis of bacterial cell walls. Ceftobiprole has high affinity for penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus strains and retains its activity against strains that express divergent mecA gene homologues. Ceftobiprole also binds to penicillin-binding protein 2b in Streptococcus pneumoniae (penicillin-intermediate), to penicillin-binding protein 2x in Streptococcus pneumoniae (penicillin-resistant), and to penicillin-binding protein 5 in Enterococcus faecalis. Wikipedia
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Anti-Infective Agents (Phase 1)
Bacteremia (Phase 2)
Bacterial Infections (Phase 3)
Cephalosporins (Phase 1)
Cerebral Ventriculitis (Phase 2)
Community-Acquired Infections (Phase 3)
Drug Resistance (Phase 1)
Fever (Phase 3)
General Surgery (Phase 1)
Gram-Positive Bacterial Infections (Phase 3)
Healthcare-Associated Pneumonia (Phase 3)
Inflammation (Phase 2)
Intensive Care Units (Phase 1)
Meningitis (Phase 2)
Neonatal Sepsis (Phase 3)
Neutropenia (Phase 3)
Obesity (Phase 1)
Pneumonia (Phase 3)
Pneumonia, Ventilator-Associated (Phase 1)
Pseudomonas Infections (Phase 3)
Skin Diseases, Bacterial (Phase 3)
Skin Diseases, Infectious (Phase 3)
Staphylococcal Infections (Phase 3)
Staphylococcal Skin Infections (Phase 3)
Streptococcal Infections (Phase 1)
| Trial | Phase | Start Date | Organizations | Indications |
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