Active Ingredient History
Brivaracetam (UCB 34714, trade name Briviact), the 4-n-propyl analog of levetiracetam, is a racetam derivative with anticonvulsant properties. Briviact is indicated as adjunctive therapy in the treatment of partial-onset seizures in patients 16 years of age and older with epilepsy. Brivaracetam is believed to act by binding to the ubiquitous synaptic vesicle glycoprotein 2A (SV2A), like levetiracetam, but with 20-fold greater affinity. There is some evidence that racetams including levetiracetam and brivaracetam access the luminal side of recycling synaptic vesicles during vesicular endocytosis. They may reduce excitatory neurotransmitter release and enhance synaptic depression during trains of high-frequency activity, such as is believed to occur during epileptic activity. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Alzheimer Disease (Phase 1/Phase 2)
Brain Neoplasms (Early Phase 1)
Cognitive Dysfunction (Phase 1/Phase 2)
Epilepsies, Partial (Phase 2)
Epilepsy ()
Epilepsy, Absence (Phase 3)
Epilepsy, Reflex (Phase 2/Phase 3)
Healthy Volunteers (Phase 1)
Neuralgia (Phase 3)
Neuralgia, Postherpetic (Phase 2)
Seizures (Phase 3)
Spinal Cord Injuries (Phase 3)
Unverricht-Lundborg Syndrome (Phase 3)
| Trial | Phase | Start Date | Organizations | Indications |
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