Active Ingredient History
Dexmedetomide (biologically active dextroisomer of medetomidine) is an alpha2-adrenergic agonist which was approved by FDA for the sedation purposes. Upon administration the drug activates the alpha2 receptors thus inhibiting the release of norepinephrine and terminating the propagation of pain signals. Also it inhibits sympathetic activity and thus can decrease blood pressure and heart rate. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Pain (approved 1999)
Abdominal Neoplasms (Phase 4)
Ablation Techniques (Phase 4)
Accidental Falls (Phase 1)
Acute Coronary Syndrome (Phase 2)
Acute Kidney Injury (Phase 4)
Acute Lung Injury (Phase 4)
Acute Pain (Phase 4)
Adenoids (Phase 4)
Aged (Phase 4)
Airway Extubation (Phase 3)
Airway Management (Early Phase 1)
Airway Obstruction (Phase 4)
Alcohol Drinking (Phase 4)
Alcohol-Induced Disorders (Phase 1)
Alcohol Withdrawal Delirium (Phase 4)
Alzheimer Disease (Phase 1)
Ambulatory Surgical Procedures (Phase 4)
Amnesia (Phase 1)
Amyotrophic Lateral Sclerosis (Phase 2)
Analgesia (Phase 4)
Analgesia, Epidural (Phase 4)
Analgesia, Obstetrical (Phase 3)
Analgesia, Patient-Controlled (Phase 4)
Analgesics (Phase 4)
Analgesics, Non-Narcotic (Phase 4)
Analgesics, Opioid (Phase 4)
Anesthesia (Phase 4)
Anesthesia and Analgesia (Phase 4)
Anesthesia, Epidural (Phase 4)
Anesthesia, General (Phase 4)
Anesthesia, Inhalation (Phase 4)
Anesthesia, Intravenous (Phase 4)
Anesthesia, Local (Phase 4)
Anesthesia, Obstetrical (Phase 3)
Anesthesia, Spinal (Phase 4)
Aneurysm (Phase 1/Phase 2)
Anterior Cruciate Ligament Injuries (Phase 4)
Anterior Temporal Lobectomy (Phase 4)
Anti-Anxiety Agents (Phase 2/Phase 3)
Anxiety (Phase 4)
Anxiety Disorders (Phase 4)
Anxiety, Separation (Phase 4)
Aorta (Phase 4)
Aortic Valve Stenosis (Phase 3)
Arm Injuries (Phase 4)
Arrhythmias, Cardiac (Phase 4)
Arteries (Phase 3)
Arteriovenous Fistula (Phase 4)
Arteriovenous Malformations (Phase 4)
Arthritis, Juvenile (Phase 4)
Arthropathy, Neurogenic (Phase 4)
Arthroplasty (Phase 3)
Arthroplasty, Replacement, Hip (Phase 4)
Arthroplasty, Replacement, Knee (Phase 4)
Arthroscopy (Phase 4)
Atrial Fibrillation (Phase 4)
Autism Spectrum Disorder (Phase 2)
Autistic Disorder (Phase 4)
Axis, Cervical Vertebra (Phase 4)
Biological Availability (Phase 3)
Bipolar Disorder (Phase 4)
Blood Pressure (Phase 4)
Brachial Plexus Block (Phase 4)
Bradycardia (Phase 4)
Brain Diseases (Phase 4)
Brain Injuries (Phase 4)
Brain Injuries, Traumatic (Phase 4)
Brain Ischemia (Phase 2)
Brain Neoplasms (Phase 4)
Breast Feeding (Phase 4)
Breast Neoplasms (Phase 4)
Bronchial Spasm (Phase 4)
Bronchoscopy (Phase 4)
Bunion (Phase 2)
Burns (Phase 2)
Cannula (Phase 4)
Cardiac Surgical Procedures (Phase 4)
Cardiopulmonary Bypass (Phase 4)
Carotid Stenosis (Phase 4)
Cataract (Phase 4)
Cell Proliferation (Phase 4)
Central Nervous System Depressants (Phase 4)
Central Nervous System Diseases (Phase 4)
Cerebral Palsy (Phase 4)
Cesarean Section (Phase 4)
Chest Pain (Phase 2)
Child Development (Phase 3)
Chills (Phase 3)
Cholecystectomy (Phase 3)
Cholecystectomy, Laparoscopic (Phase 4)
Cholecystitis, Acute (Phase 4)
Chronic Pain (Phase 4)
Cleft Lip (Phase 4)
Cleft Palate (Phase 4)
Cocaine-Related Disorders (Phase 1)
Cognition Disorders (Phase 4)
Cognitive Aging (Phase 4)
Cognitive Dysfunction (Phase 4)
Colonic Diseases (Phase 3)
Colonic Neoplasms (Phase 4)
Colonoscopy (Phase 4)
Colorectal Surgery (Phase 4)
Confusion (Phase 4)
Consciousness (Phase 4)
Consciousness Disorders (Phase 4)
Conscious Sedation (Phase 4)
Coronary Artery Bypass (Phase 4)
Coronary Artery Disease (Phase 4)
Coronary Disease (Phase 4)
Cough (Phase 4)
COVID-19 (Phase 4)
Craniofacial Abnormalities (Phase 2)
Craniotomy (Phase 4)
Critical Care (Phase 2)
Critical Illness (Phase 4)
Cryptorchidism (Phase 2)
Cystitis, Interstitial (Phase 4)
Deep Brain Stimulation (Phase 4)
Deep Sedation (Phase 4)
Deglutition (Phase 4)
Delayed Emergence from Anesthesia (Phase 4)
Delirium (Phase 4)
Dementia (Phase 3)
Dental Anxiety (Phase 4)
Dental Caries (Phase 4)
Depression (Phase 4)
Depressive Disorder, Major (Phase 4)
Dermatology (Phase 4)
Dexamethasone (Phase 4)
Dexmedetomidine (Phase 4)
Diabetes Mellitus (Phase 4)
Diagnosis (Phase 3)
Dose-Response Relationship, Drug (Phase 4)
Drug Delivery Systems (Phase 4)
Drug Misuse (Phase 4)
Drugs, Investigational (Phase 4)
Dysautonomia, Familial (Phase 2)
Dyspnea (Phase 2)
Dystonia (Phase 2/Phase 3)
Elective Surgical Procedures (Phase 3)
Emergence Delirium (Phase 4)
Emergencies (Phase 4)
Endometrial Neoplasms (Phase 4)
Endothelial Cells (Phase 4)
Epigenomics (Phase 4)
Epilepsy (Phase 4)
Essential Hypertension (Phase 3)
Essential Tremor (Phase 2/Phase 3)
Evoked Potentials, Auditory, Brain Stem (Phase 3)
Executive Function (Phase 3)
Fasting (Phase 4)
Femoral Fractures (Phase 3)
Fentanyl (Phase 4)
Forearm Injuries (Phase 4)
Fractures, Bone (Phase 4)
Frailty (Phase 4)
Functional Status (Phase 4)
Gabapentin (Phase 3)
Gastrectomy (Phase 4)
Gastric Emptying (Phase 1)
Gastrointestinal Diseases (Phase 3)
Gene Expression (Phase 4)
General Surgery (Phase 4)
Genital Diseases, Female (Phase 4)
Geriatrics (Early Phase 1)
Glaucoma (Phase 4)
Growth and Development (Phase 4)
Hand Injuries (Phase 4)
Headache (Phase 4)
Healthy Volunteers (Phase 4)
Heart Defects, Congenital (Phase 2)
Heart Diseases (Phase 4)
Heart Injuries (Early Phase 1)
Heart Rate (Phase 2/Phase 3)
Heart Septal Defects, Atrial (Phase 4)
Heart Septal Defects, Ventricular (Phase 1)
Heart Transplantation (Phase 3)
Heart Valve Diseases (Phase 4)
Heart Ventricles (Phase 1)
Hemodynamics (Phase 4)
Hemorrhage (Phase 4)
Hepatectomy (Early Phase 1)
Hernia, Inguinal (Phase 3)
Hip Fractures (Phase 4)
Hip Injuries (Phase 4)
HIV (Phase 2)
HIV Infections (Phase 4)
Hydrocephalus (Phase 4)
Hypertension (Phase 4)
Hypertension, Pulmonary (Phase 2/Phase 3)
Hypnotics and Sedatives (Phase 4)
Hypospadias (Phase 4)
Hypotension (Phase 1)
Hypothermia (Phase 4)
Hypoxia (Phase 4)
Hypoxia-Ischemia, Brain (Phase 2)
Hysterectomy (Phase 2/Phase 3)
Hysterectomy, Vaginal (Phase 3)
Immune System Diseases (Phase 1/Phase 2)
Infertility, Male (Early Phase 1)
Inflammation (Phase 4)
Injections, Intra-Articular (Phase 4)
Intensive Care Units (Phase 4)
Intensive Care Units, Neonatal (Phase 3)
Intestinal Diseases (Phase 2)
Intestinal Neoplasms (Phase 4)
Intracranial Aneurysm (Phase 4)
Intracranial Hemorrhages (Phase 2)
Intracranial Pressure (Phase 3)
Intraocular Pressure (Phase 4)
Intraoperative Awareness (Phase 2)
Intraoperative Complications (Phase 4)
Intubation (Phase 4)
Intubation, Intratracheal (Phase 4)
Ischemic Stroke (Phase 4)
Ketamine (Phase 4)
Kidney Diseases (Phase 4)
Kidney Failure, Chronic (Phase 3)
Kidney Neoplasms (Phase 4)
Kidney Transplantation (Phase 4)
Knee Injuries (Phase 4)
Labor Pain (Phase 4)
Lacerations (Phase 4)
Laparoscopy (Phase 4)
Laryngoscopy (Phase 4)
Length of Stay (Phase 4)
Levobupivacaine (Phase 4)
Lidocaine (Phase 4)
Limb Deformities, Congenital (Phase 4)
Liver Cirrhosis (Phase 3)
Liver Diseases (Phase 4)
Liver Neoplasms (Phase 4)
Liver Transplantation (Phase 4)
Lumbar Vertebrae (Phase 4)
Lung Diseases (Phase 4)
Lung Neoplasms (Phase 4)
Lymphatic Diseases (Early Phase 1)
Lymph Nodes (Phase 4)
Lymphoma (Phase 3)
Magnesium Sulfate (Phase 4)
Magnetic Resonance Imaging (Phase 4)
Malocclusion, Angle Class III (Phase 4)
Mandibular Diseases (Phase 4)
Mastectomy (Phase 4)
Mastectomy, Modified Radical (Phase 4)
Memory Disorders (Phase 1)
Menstrual Cycle (Phase 4)
Mental Disorders (Phase 4)
Metabolic Diseases (Phase 4)
Microcirculation (Phase 4)
Midazolam (Phase 4)
Mortality (Phase 4)
Musculoskeletal Diseases (Phase 4)
Myocardial Reperfusion Injury (Phase 4)
Myocardium (Phase 4)
Myoclonus (Phase 4)
Myoma (Phase 3)
Myringoplasty (Phase 4)
Narcotics (Phase 3)
Nasal Obstruction (Phase 4)
Nasal Polyps (Phase 1)
Nausea (Phase 4)
Neoplasms (Phase 4)
Nerve Block (Phase 4)
Nervous System Diseases (Phase 4)
Neuralgia (Phase 4)
Neurobehavioral Manifestations (Phase 4)
Neurocognitive Disorders (Phase 4)
Neurodevelopmental Disorders (Phase 3)
Neurofibromatoses (Phase 4)
Neurologic Manifestations (Phase 4)
Neuromuscular Blockade (Phase 4)
Obesity (Phase 4)
Obesity, Morbid (Phase 4)
Obsessive Behavior (Phase 4)
Only Child (Phase 2/Phase 3)
Opioid-Related Disorders (Phase 4)
Orthognathic Surgery (Phase 4)
Orthopedic Procedures (Phase 4)
Orthopedics (Phase 4)
Osteoarthritis (Phase 4)
Osteoarthritis, Knee (Phase 4)
Otitis (Phase 4)
Otitis Media (Phase 2/Phase 3)
Oxidative Stress (Phase 4)
Oximetry (Phase 3)
Pain (Phase 4)
Pain, Intractable (Phase 2/Phase 3)
Pain Management (Phase 3)
Pain, Postoperative (Phase 4)
Pain, Procedural (Phase 3)
Palliative Care (Phase 4)
Pancreatic Neoplasms (Phase 4)
Pancreatitis (Phase 4)
Pancreatitis, Acute Necrotizing (Phase 4)
Parkinson Disease (Phase 4)
Parkinsonian Disorders (Phase 4)
Pathologic Processes (Phase 4)
Patient Outcome Assessment (Phase 4)
Pediatrics (Phase 4)
Penile Diseases (Phase 4)
Penis (Phase 4)
Perioperative Care (Phase 4)
Perioperative Period (Phase 4)
Peritonitis (Phase 4)
Persistent Vegetative State (Phase 4)
Personal Satisfaction (Phase 4)
Pharmaceutical Preparations (Phase 4)
Pharmacokinetics (Phase 4)
Pharmacology (Phase 1/Phase 2)
Pharyngitis (Phase 3)
Pheochromocytoma (Phase 2)
Phimosis (Phase 4)
Physiological Effects of Drugs (Phase 4)
Pituitary Neoplasms (Phase 4)
Pneumonia (Phase 4)
Pneumonia, Aspiration (Phase 4)
Post-Dural Puncture Headache (Phase 3)
Postoperative Care (Phase 2)
Postoperative Cognitive Complications (Phase 4)
Postoperative Complications (Phase 4)
Postoperative Nausea and Vomiting (Phase 4)
Postoperative Period (Phase 4)
Preanesthetic Medication (Phase 4)
Pre-Eclampsia (Phase 2/Phase 3)
Pregabalin (Phase 4)
Pregnancy (Phase 2)
Pregnancy Complications (Phase 4)
Premedication (Phase 4)
Preoperative Care (Phase 4)
Propofol (Phase 4)
Psychological Distress (Phase 4)
Psychomotor Agitation (Phase 4)
Psychomotor Performance (Phase 3)
Psychoses, Substance-Induced (Phase 4)
Psychotic Disorders (Phase 4)
Pulmonary Atelectasis (Phase 4)
Pulmonary Disease, Chronic Obstructive (Phase 4)
Quality of Life (Phase 4)
Radiofrequency Ablation (Phase 4)
Radius Fractures (Phase 4)
Rapid Sequence Induction and Intubation (Phase 3)
Reflex, Abnormal (Phase 4)
Reflex, Oculocardiac (Phase 4)
Remifentanil (Phase 4)
Renal Insufficiency (Phase 1)
Reperfusion Injury (Phase 4)
Respiration, Artificial (Phase 4)
Respiratory Distress Syndrome (Phase 4)
Respiratory Insufficiency (Phase 4)
Respiratory Tract Infections (Phase 4)
Retinal Detachment (Phase 4)
Retinopathy of Prematurity (Phase 3)
Rhinoplasty (Phase 4)
Rib Fractures (Phase 4)
Ropivacaine (Phase 4)
SARS-CoV-2 (Phase 4)
Schizophrenia (Phase 4)
Scoliosis (Phase 4)
Scopolamine (Phase 2)
Self Efficacy (Phase 3)
Sepsis (Phase 4)
Shivering (Phase 4)
Shock (Phase 1)
Shock, Septic (Phase 4)
Shoulder (Early Phase 1)
Shoulder Injuries (Phase 4)
Shoulder Pain (Phase 4)
Signs and Symptoms (Phase 4)
Sinusitis (Phase 4)
Skull (Early Phase 1)
Sleep (Phase 4)
Sleep Apnea, Obstructive (Phase 4)
Sleep Apnea Syndromes (Phase 3)
Sleep Deprivation (Phase 4)
Sleep Disorders, Intrinsic (Phase 4)
Sleep Quality (Phase 4)
Sleep Wake Disorders (Phase 4)
Snoring (Phase 4)
Spinal Diseases (Phase 4)
Spinal Fusion (Phase 4)
Spinal Injuries (Phase 4)
Spinal Stenosis (Phase 4)
Spine (Phase 4)
Spondylolisthesis (Phase 2/Phase 3)
Spondylolysis (Phase 2/Phase 3)
Stomach Neoplasms (Phase 4)
Strabismus (Phase 4)
Stress Disorders, Post-Traumatic (Phase 3)
Stress Disorders, Traumatic, Acute (Phase 2)
Stroke (Phase 2)
Subarachnoid Hemorrhage (Phase 3)
Substance Withdrawal Syndrome (Phase 3)
Suburethral Slings (Phase 3)
Sufentanil (Phase 4)
Supratentorial Neoplasms (Phase 4)
Surgical Procedures, Operative (Phase 4)
Survival (Phase 4)
Survivors (Phase 4)
Tachycardia (Phase 2)
Temporomandibular Joint Disorders (Phase 2)
Tetralogy of Fallot (Phase 2/Phase 3)
Therapeutics (Phase 2/Phase 3)
Thoracic Injuries (Phase 4)
Thoracic Surgery (Phase 4)
Thoracoscopy (Phase 4)
Thyroidectomy (Phase 4)
Thyroid Gland (Phase 4)
Tinnitus (Phase 4)
Tomography (Phase 4)
Tonsillectomy (Phase 4)
Tonsillitis (Phase 4)
Tooth (Phase 3)
Tourniquets (Phase 4)
Trachea (Phase 2/Phase 3)
Transcatheter Aortic Valve Replacement (Phase 4)
Transurethral Resection of Prostate (Phase 4)
Traumatology (Phase 4)
Treatment Refusal (Phase 4)
Tremor (Phase 3)
Tricuspid Atresia (Phase 1)
Turbinates (Phase 4)
Ulna Fractures (Phase 4)
Ultrasonography (Phase 4)
Unconsciousness (Phase 4)
Upper Extremity (Phase 4)
Urethral Diseases (Phase 4)
Urinary Bladder Neoplasms (Phase 4)
Uterine Myomectomy (Phase 2/Phase 3)
Vascular Diseases (Early Phase 1)
Vasoconstriction (Early Phase 1)
Vasodilation (Early Phase 1)
Vasopressins (Phase 3)
Vasospasm, Intracranial (Phase 2)
Venous Cutdown (Phase 4)
Ventilation (Phase 4)
Ventilators, Mechanical (Phase 4)
Ventilator Weaning (Phase 2)
Vital Signs (Phase 1)
Wound Healing (Phase 4)
Wounds and Injuries (Phase 2/Phase 3)
Wrist Injuries (Phase 4)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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