Active Ingredient History
Tetrahydrobiopterin (BH4, THB), also known as sapropterin (INN), is a cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the production of nitric oxide (NO) by the nitric oxide synthases. Chemically, its structure is that of a (dihydropteridine reductase) reduced pteridine derivative (quinonoid dihydrobiopterin). Wikipedia
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Cardiovascular Diseases (Phase 1)
Cystic Fibrosis (Phase 2)
Enteritis (Phase 2)
Heart Disease Risk Factors (Phase 1)
Heart Failure (Phase 1)
Heart Failure, Systolic (Early Phase 1)
Hypertension (Phase 1)
Hypertension, Pulmonary (Phase 1)
Intermittent Claudication (Phase 1)
Oxidative Stress (Phase 1)
Peripheral Arterial Disease (Phase 1)
Peripheral Vascular Diseases (Phase 1)
Phenylketonurias (Phase 4)
Pulmonary Disease, Chronic Obstructive (Phase 1)
Radiodermatitis (Phase 1)
Rheumatology (Phase 1/Phase 2)
Vasoconstriction (Phase 1)
Trial | Phase | Start Date | Organizations | Indications |
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