cocarboxylase Report issue

Small molecule Experimental

Active Ingredient History

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Cocarboxylase is the coenzyme form of Vitamin B1 present in many animal tissues. Thiamine pyrophosphate (cocarboxylase) is the active form of thiamine, and it serves as a cofactor for several enzymes involved primarily in carbohydrate catabolism. Pancreatic cells obtain thiamin from their surroundings and enzymatically convert it into thiamin pyrophosphate (TPP) in the cytoplasm; TPP is then taken up by mitochondria via a specific carrier the mitochondrial TPP transporter (MTPPT; product of the SLC25A19 gene).   NCATS

Chemistry

  • SMILES: [H+].CC1=C(CCOP([O-])(=O)OP(O)([O-])=O)SC=[N+]1CC2=CN=C(C)N=C2N
  • InChIKey: AYEKOFBPNLCAJY-UHFFFAOYSA-N
  • Mol. Mass: 424.306
  • ALogP: Missing data
  • ChEMBL Molecules: Missing data
More Chemistry

Pharmacology

Organizations (1)

Research & Development (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (2)

Approved Indications (1)


 

Avitaminosis (approved 1999)

Experimental Indications - Clinical Trial Phases 1-4 (1)


 

Thiamine Deficiency (Phase 1)

Overview

  • Highest Phase: N/A
  • # of Trials: 1
  • # of Trial Organizations: 1

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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