API | martinostat

martinostat Report issue

Small molecule Experimental

Active Ingredient History

NOW

Martinostat is a histone deacetylase inhibitor (HDACi) that is potent against recombinant class I HDACs and class IIb HDAC with low nanomolar affinities. In tissue CETSA assays, martinostat exhibits selectivity for class I HDACs. When tagged with the radioisotope carbon-11, martinostat can be used to quantify HDAC in the brain and peripheral organs using positron emission tomography. Martinostat was given a name that adopted the style of other HDAC inhibitors, such as vorinostat, entinostat, and crebinostat, that recognized the academic center in which it was developed, the Martinos Center for Biomedical Imaging. ^Wikipedia

Chemistry

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More Chemistry

Pharmacology

Mechanisms of Action:
- Histone deacetylase 1 (Mus musculus) ^UniProt
- Histone deacetylase 2 (Homo sapiens) ^UniProt
- Histone deacetylase 3 (Homo sapiens) ^UniProt
- Histone deacetylase 6 (Mus musculus) ^UniProt
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Organizations (1)

Research & Development (1)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

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Indications (1)

Approved Indications (0)

Experimental Indications - Clinical Trial Phases 1-4 (1)

Breast Neoplasms (Phase 1)

Overview

Highest Phase: Phase 1
# of Trials: 2
# of Trial Organizations: 1

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

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