API | urapidil

urapidil Report issue

Small molecule Experimental

Active Ingredient History

NOW

Urapidil is a sympatholytic antihypertensive drug. It acts as an α1-adrenoceptor antagonist and as an 5-HT1A receptor agonist. Although an initial report suggested that urapidil was also an α2-adrenoceptor agonist, this was not substantiated in later studies that demonstrated it was devoid of agonist actions in the dog saphenous vein and the guinea-pig ileum. Unlike some other α1-adrenoceptor antagonists, urapidil does not elicit reflex tachycardia, and this may be related to its weak β1-adrenoceptor antagonist activity, as well as its effect on cardiac vagal drive. Urapidil is currently not approved by the U.S. Food and Drug Administration, but it is available in Europe. ^Wikipedia

Chemistry

SMILES: Missing data
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More Chemistry

Pharmacology

Mechanisms of Action:
- Alpha-1A adrenergic receptor (Homo sapiens) ^UniProt
- 5-hydroxytryptamine receptor 1A (Homo sapiens) ^UniProt
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Organizations (7)

Research & Development (7)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (7)

Approved Indications (2)

Eclampsia

Pre-Eclampsia

Experimental Indications - Clinical Trial Phases 1-4 (5)

Cerebrovascular Disorders (Phase 3)

Essential Hypertension ()

Ischemic Stroke (Phase 4)

Stroke (Phase 3)

Traumatology (Phase 4)

Overview

Highest Phase: Phase 4
# of Trials: 5
# of Trial Organizations: 7

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

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