Active Ingredient History
S-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or AdoMet, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver. More than 40 methyl transfers from SAM are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase. SAM was first discovered by Giulio Cantoni in 1952. Wikipedia
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Alcohol Withdrawal Delirium (Phase 3)
Carcinoma, Hepatocellular (Phase 1)
Cholestasis (Phase 4)
Depression (Phase 2/Phase 3)
Depressive Disorder, Major (Phase 1)
Fibromyalgia (Phase 2)
Healthy Volunteers (Phase 2)
Hepatitis (Phase 3)
Hepatitis, Alcoholic (Phase 4)
Hepatitis B (Phase 4)
Hepatitis C (Phase 2/Phase 3)
Hepatitis C, Chronic (Phase 2)
HIV Infections (Phase 4)
Hot Flashes (Phase 2)
Hyperhomocysteinemia (Phase 1)
Liver Cirrhosis, Biliary (Phase 4)
Liver Diseases, Alcoholic (Phase 3)
Liver Neoplasms (Phase 2)
Non-alcoholic Fatty Liver Disease (Phase 3)
Parkinson Disease (Phase 2/Phase 3)
Tobacco Use Disorder (Phase 2/Phase 3)
Trial | Phase | Start Date | Organizations | Indications |
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