Active Ingredient History
Histamine is a depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Phosphate salt of jistamine was used as a diagnostic aid for evaluation of gastric acid secretory function. In addition, this compound is used as a positive control in evaluation of allergenic (immediate hypersensitivity or "Type I") skin testing. In addition, histamine is being studied for treatment of multiple sclerosis. It was approved, that histamine physiological functions are mediated by four 7-transmembrane G protein-coupled receptors (H1R, H2R, H3R, H4R) that are all targets of pharmacological intervention. The receptors display molecular heterogeneity and constitutive activity. H1R antagonists are long known antiallergic and sedating drugs, whereas the H2R led to the development of H2R-antagonists that revolutionized stomach ulcer treatment. The H3R is an auto receptor and heteroreceptor providing negative feedback on histaminergic and inhibition on other neurons. The H4R occurs on immuncompetent cells and the development of anti-inflammatory drugs is anticipated. NCATS
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Allergy and Immunology (Early Phase 1)
Asthma (Phase 2)
Back Pain (Phase 4)
Dermatology (Phase 2)
General Surgery (Phase 2)
Healthy Volunteers (Phase 1)
Immune System Diseases (Phase 2/Phase 3)
Immunosuppression Therapy (Phase 2)
Influenza, Human (Phase 2/Phase 3)
Kidney Neoplasms (Phase 2)
Knee Injuries (Phase 4)
Leukemia (Phase 3)
Leukemia, Myeloid, Acute (Phase 4)
Leukemia, Myelomonocytic, Chronic (Phase 1/Phase 2)
Low Back Pain (Phase 3)
Melanoma (Phase 3)
Migraine Disorders (Phase 4)
Multiple Sclerosis (Phase 2)
Myelodysplastic Syndromes (Phase 1/Phase 2)
Neoplasm Metastasis (Phase 2)
Neoplasms (Phase 3)
Osteoarthritis, Knee (Phase 3)
Pain (Phase 4)
Pancreatic Neoplasms (Phase 2)
Respiratory Tract Infections (Phase 2/Phase 3)
Rhinitis, Allergic, Seasonal (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
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