Active Ingredient History
Leronlimab is a humanized monoclonal antibody targeted against the CCR5 receptor found on T lymphocytes of the human immune system. It is being investigated as a potential therapy in the treatment of COVID-19, triple negative breast cancer, and HIV infection. The United States Food and Drug Administration has designated PRO 140 for fast-track approval. In February 2008, the drug entered Phase 2 clinical trials and a phase 3 trial was begun in 2015. In February 2018, Cytodyn Inc reported that the primary endpoint had been achieved in the PRO 140 pivotal combination therapy trial in HIV infection. In 2020 CytoDyn submitted a fast-track biologics license application for treatment of CCR5-tropic HIV-1 Infection. Wikipedia
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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CCR5 Receptor Antagonists (Phase 2)
Colorectal Neoplasms (Phase 2)
COVID-19 (Phase 3)
Microsatellite Instability (Phase 2)
Neoplasm Metastasis (Phase 2)
Neoplasms (Phase 2)
Non-alcoholic Fatty Liver Disease (Phase 2)
Triple Negative Breast Neoplasms (Phase 1/Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
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