adagrasib (Krazati) Report issue

Small molecule Orphan Drug FDA Approved FDA Fast Track FDA Breakthrough Therapy FDA Accelerated Approval FDA

Active Ingredient History

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Chemistry

  • SMILES: C=C(F)C(=O)N1CCN(c2nc(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(Cl)c24)C3)C[C@@H]1CC#N
  • InChIKey: PEMUGDMSUDYLHU-ZEQRLZLVSA-N
  • Mol. Mass: 604.13
  • ALogP: 4.73
  • ChEMBL Molecule:
    adagrasib  
More Chemistry

Pharmacology

Organizations (10)

Research & Development (10)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (12)

Approved Indications (1)


 

Carcinoma, Non-Small-Cell Lung (approved 2022)

Experimental Indications - Clinical Trial Phases 1-4 (12)


 

Carcinoma, Non-Small-Cell Lung (Phase 3)

Colonic Neoplasms (Phase 1)

Colorectal Neoplasms (Phase 3)

Healthy Volunteers (Phase 1)

Intestinal Neoplasms (Phase 1)

Lung Neoplasms (Phase 2)

Mutation (Phase 1/Phase 2)

Neoplasm Metastasis (Phase 1/Phase 2)

Neoplasms (Phase 2)

Pancreatic Neoplasms (Phase 1)

Proto-Oncogene Proteins p21(ras) (Phase 2)

Small Cell Lung Carcinoma (Phase 3)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 23
  • # of Trial Organizations: 10

Trials by Phase

Trial Phase Start Date Organizations Indications

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