Active Ingredient History
A CXCR4 antagonist is a substance which blocks the CXCR4 receptor and prevent its activation. Blocking the receptor stops the receptor's ligand, CXCL12, from binding which prevents downstream effects. CXCR4 antagonists are especially important for hindering cancer progression because one of the downstream effects initiated by CXCR4 receptor activation is cell movement which helps the spread of cancer, known as metastasis. The CXCR4 receptor has been targeted by antagonistic substances since being identified as a co-receptor in HIV and assisting the development of cancer. Macrocyclic ligands have been utilised as CXCR4 antagonists. Wikipedia
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Multiple Myeloma (approved 2023)
Adenocarcinoma (Phase 2)
Anemia, Sickle Cell (Phase 1)
Esophageal Neoplasms (Phase 1/Phase 2)
Healthy Volunteers (Phase 1)
Multiple Myeloma (Phase 3)
Pancreatic Neoplasms (Phase 2)
Trial | Phase | Start Date | Organizations | Indications |
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