API | benzhydrocodone

benzhydrocodone (Apadaz) Report issue

Small molecule Approved ^FDA Priority Review ^FDA

Active Ingredient History

NOW

Benzhydrocodone (INN) is an opioid prodrug of the morphinan class. Its chemical structure consists of hydrocodone coupled with benzoic acid. Benzhydrocodone itself is inactive and acts as a prodrug to hydrocodone upon cleavage of the benzoate portion of the molecule. ^Wikipedia

Chemistry

SMILES: COc1ccc2c3c1O[C@H]1C(OC(=O)c4ccccc4)=CC[C@@H]4[C@@H](C2)N(C)CC[C@@]341.Cl
InChIKey: VVCUIDHKAHHSAN-JJHQWJQCSA-N
Mol. Mass: 439.94
ALogP: 3.72 Partition coefficient
ChEMBL Molecules:

benzhydrocodone hydrochloride

benzhydrocodone

More Chemistry

Pharmacology

Mechanisms of Action:
- Mu-type opioid receptor (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: No
Availability: Prescription Only
Delivery Methods: Oral
Pro Drug: No

Combination drugs

apadaz ( acetaminophen (tylenol), benzhydrocodone (Apadaz) )

Organizations (3)

Research & Development (1)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (2)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (4)

Approved Indications (1)

Acute Pain (approved 2018)

Experimental Indications - Clinical Trial Phases 1-4 (3)

Nausea (Phase 3)

Pain (Phase 3)

Vomiting (Phase 3)

Overview

Highest Phase: Phase 3
# of Trials: 1
# of Trial Organizations: 1

Trials by Phase

Trial	Phase	Start Date	Organizations	Indications

Feedback

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