sulfadoxine Report issue

Small molecule Approved FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Sulfadoxine is an antimalarial agent which, together with pyrimethamine, composes an FDA-approved drug, Fansidar. Sulfadoxine acts by inhibiting dihydropteroate synthase; it crosses the blood-brain barrier and achieves 30% to 60% of the plasma concentration.   NCATS

Chemistry

  • SMILES: COC1=C(OC)C(NS(=O)(=O)C2=CC=C(N)C=C2)=NC=N1
  • InChIKey: PJSFRIWCGOHTNF-UHFFFAOYSA-N
  • Mol. Mass: 310.329
  • ALogP: 0.88
  • ChEMBL Molecule:
    sulfadoxine  
More Chemistry

Pharmacology

Combination drugs

( sulfadoxine, pyrimethamine (daraprim) )

Alternative names

4-sulfanilamido-5,6-dimethoxypyrimidine | fanasil | fansidar | fanzil | orthosulfin | ro-44393 | sulfadoxin | sulfadoxina | sulfadoxine | sulfadoxinum | sulformethoxine | sulformetoxin | sulformetoxine | sulforthamidine | sulforthodimethoxine | sulforthomidine | sulphadoxine | sulphormethoxine

Organizations (175)

Research & Development (174)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (38)

Approved Indications (2)


 

Malaria, Falciparum (approved 1981)

Toxoplasmosis

Experimental Indications - Clinical Trial Phases 1-4 (37)


 

Acquired Immunodeficiency Syndrome (Phase 4)

Anemia (Phase 4)

Anemia, Sickle Cell (Phase 3)

Autoimmune Diseases (Phase 1)

Cardiotoxicity (Phase 2)

Child Mortality (Phase 3)

Healthy Volunteers (Phase 3)

HIV (Phase 4)

HIV Infections (Phase 4)

Infant, Premature, Diseases (Phase 4)

Lymphoproliferative Disorders (Phase 1)

Malaria (Phase 4)

Malaria, Falciparum (Phase 4)

Malaria, Vivax (Phase 3)

Only Child (Phase 3)

Parasitemia (Phase 3)

Parasitic Diseases (Phase 3)

Perinatal Death (Phase 4)

Pharmacokinetics (Phase 4)

Pharmacological and Toxicological Phenomena (Phase 2)

Plasmodium (Phase 4)

Plasmodium falciparum (Phase 3)

Pneumonia, Pneumocystis (Phase 3)

Precursor Cell Lymphoblastic Leukemia-Lymphoma (Phase 4)

Pregnancy (Phase 4)

Pregnancy Complications (Phase 4)

Premature Birth (Phase 3)

Respiratory Tract Infections (Phase 3)

Schistosomiasis haematobia (Phase 2)

Sexually Transmitted Diseases (Phase 3)

Stillbirth (Phase 4)

Therapeutic Equivalency (Phase 1)

Treatment Adherence and Compliance (Phase 4)

Treatment Outcome (Phase 4)

Trichomonas Vaginitis (Phase 3)

Vaginosis, Bacterial (Phase 3)

Wound Infection (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 155
  • # of Trial Organizations: 174

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue