dihydroergocornine mesylate Report issue

Small molecule Experimental
Drug Central MeSH PubChem

Active Ingredient History

Dihydroergocornine is an ergot alkaloid, one of the three components of ergoloid (trade name Hydergine). Dihydroergocornine (as the component of Ergoloid mesylates) has been used to treat dementia and age-related cognitive impairment (such as in Alzheimer disease), as well as to aid in recovery after stroke. There is no specific evidence which clearly establishes the mechanism by which Hydergine® (ergoloid mesylates) preparations produce mental effects, nor is there conclusive evidence that the drug particularly affects cerebral arteriosclerosis or cerebrovascular insufficiency. Hydergine may stimulates dopaminergic and serotonergic receptors and blocks alpha-adrenoreceptors.   NCATS

Chemistry

  • SMILES: CC(C)[C@@H]1N2C(=O)[C@](NC(=O)[C@@H]3C[C@H]4[C@@H](CC5=CNC6=C5C4=CC=C6)N(C)C3)(O[C@@]2(O)[C@@H]7CCCN7C1=O)C(C)C
  • InChIKey: SEALOBQTUQIVGU-QNIJNHAOSA-N
  • Mol. Mass: 563.6877
  • ALogP: Missing data
  • ChEMBL Molecules: Missing data
More Chemistry

Pharmacology

Alternative names

9,10-dihydroergocornine | dihydroergocornine | dihydroergocornine mesilate | dihydroergocornine mesylate

Indications (3)

Approved Indications (2)


 

Alzheimer Disease (approved 1977)

Dementia (approved 1977)

Experimental Indications - Clinical Trial Phases 1-4 (1)


 

Dementia, Vascular (Phase 2)

Feedback

Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue