choline c11 (choline c-11) Report issue

Small molecule Imaging Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Choline C 11 injection was approved to help diagnose recurrent prostate cancer. It is used for a procedure called positron emission tomography (PET) scan to detect tumors that are not detectable by other scanning procedures, such as bone scan, computed tomography (CT), or magnetic resonance imaging (MRI). Choline C 11 is a radioactive diagnostic agent, the analog of choline. Choline is involved in the synthesis of the structural components of cell membranes, as well as modulation of transmembrane signaling. Increased phospholipid synthesis (i.e., increased uptake of choline) has been associated with cell proliferation and the transformation process that occurs in tumor cells. Recently, Choline C 11 PET was studied for diagnosis the patients with hepatocellular carcinoma; although the phase II of clinical trials was not begun.   NCATS

Chemistry

More Chemistry

Pharmacology

  • Mechanisms of Action:
  • Multi-specific: Missing data
  • Imaging: 11-carbon
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: No

Alternative names

11c-choline | 11c-choline chloride | bilineurine | biscolan | c-11 choline | c11-choline | choline | choline (11c) | choline bitartrate | choline c11 | choline c 11 | choline c-11 | choline c 11 injection | choline c11 injection | choline chloride | choline dehydrocholate | choline dihydrogencitrate | f-choline | n,n,n-trimethylethanol-ammonium | n-trimethylethanolamine | trimethylethanolamine | vitamin j

Organizations (57)

Research & Development (55)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (7)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (25)

Approved Indications (1)


 

Prostatic Neoplasms (approved 2012)

Experimental Indications - Clinical Trial Phases 1-4 (25)


 

Alcoholism (Phase 1/Phase 2)

Antimetabolites (Phase 4)

Asthma (Phase 3)

Autistic Disorder (Phase 4)

Carcinoma, Hepatocellular (Phase 2)

Child Development (Phase 1)

Diet Therapy (Early Phase 1)

Dyslipidemias (Phase 1/Phase 2)

Esophageal Neoplasms (Phase 1)

Fatty Liver (Phase 4)

Fetal Alcohol Spectrum Disorders (Phase 2)

Fetal Distress (Phase 1)

Healthy Volunteers (Phase 1)

Hyperhomocysteinemia (Phase 3)

Inflammation (Phase 4)

Liver Cirrhosis (Phase 3)

Liver Diseases (Phase 2)

Lymphangioleiomyomatosis (Early Phase 1)

Macular Edema (Phase 2)

Metabolic Syndrome (Phase 3)

Non-alcoholic Fatty Liver Disease (Phase 3)

Obesity (Phase 3)

Pain, Postoperative (Phase 4)

Pregnancy (Phase 1)

Prostatic Neoplasms (Phase 3)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 42
  • # of Trial Organizations: 55

Trials by Phase

Trial Phase Start Date Organizations Indications

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