Active Ingredient History

NOW
  • Now
Paromomycin is a broad spectrum aminoglycoside antibiotic produced by by Streptomyces rimosus var. paromomycinus and used to treat intestinal infections such as cryptosporidiosis and amoebiasis, and other diseases such as leishmaniasis. Paromomycin is also used for the management of hepatic coma as adjunctive therapy. Paromomycin inhibits protein synthesis by binding to bacterial or protozoal 16S ribosomal RNA which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death. Gastrointestinal side effects include nausea, vomiting, diarrhea, and abdominal discomfort.   NCATS

  • SMILES: NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O
  • InChIKey: UOZODPSAJZTQNH-LSWIJEOBSA-N
  • Mol. Mass: 615.63
  • ALogP: -8.86
  • ChEMBL Molecules:
More Chemistry
(1r,2r,3s,4r,6s)-4,6-diamino-2-{[3-o-(2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl)-beta-d-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-d-glucopyranoside | ameparomo | aminosidin | aminosidine | aminosidine sulfate | catenulin | crestomycin | crestomycin sulfate | estomycin | estomycin sulfate | gabbroral | gentamicin sulfate mixture with paromomycin sulfate | humatin | hydroxymycin | liposomal paromomycin | monomycin | monomycin a | neomycin e | neosporin | paramomycin | parmomycin | paromomicina | paromomycin | paromomycine | paromomycin i | paromomycin sulfate | paromomycin sulphate | paromomycinum | paromycin | paucimycin | paucimycinum | polysporin | zygomycin a1

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