dihydroergocryptine mesylate Report issue

Small molecule Experimental
ChEMBL Drug Central KEGG MeSH PubChem

Active Ingredient History

Dihydro-alpha-ergocryptine is an ergot alkaloid that has an agonist activity on D2 dopaminergic receptors and a partial agonist activity on D1 receptors. It also demonstrated antagonistic activity towards alpha-adrenergic receptors. The drug was approved by FDA in combination with other alkaloids (dihydroergocornine, dihydroergocristine and dihydro-beta-ergocryptine mesylate salts) under the name Hydergine for the treatment of dimentia and cerebrovascular insufficiency.   NCATS

Chemistry

  • SMILES: CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12
  • InChIKey: PBUNVLRHZGSROC-VTIMJTGVSA-N
  • Mol. Mass: 577.73
  • ALogP: 2.52
  • ChEMBL Molecules:
    dihydroergocryptine  
    dihydroergocryptine mesylate  
More Chemistry

Pharmacology

Alternative names

dihydro-.alpha.-ergocryptine | dihydro-.alpha.-ergocryptine mesilate | dihydro-.alpha.-ergocryptine mesylate | dihydroergocriptine | dihydroergocryptine mesilate | dihydroergocryptine mesylate

Indications (2)

Approved Indications (2)


 

Cerebrovascular Disorders (approved 1977)

Dementia (approved 1977)

Experimental Indications - Clinical Trial Phases 1-4 (0)

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