tazobactam (Zosyn) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Tazobactam is a beta-lactamase inhibitor, which was approved by FDA for the treatment of wide range of bacterial infections either in combination with piperacillin (Zosyn) or with ceftolozane (Zerbaxa).   NCATS

Chemistry

  • SMILES: C[C@]1(Cn2ccnn2)[C@@H](N3[C@@H](CC3=O)S1(=O)=O)C(=O)O
  • InChIKey: LPQZKKCYTLCDGQ-WEDXCCLWSA-N
  • Mol. Mass: 300.3
  • ALogP: -1.52
  • ChEMBL Molecules:
    tazobactam  
    tazobactam sodium  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Parenteral
  • Pro Drug: No

Combination drugs

( ceftolozane (Zerbaxa), tazobactam (Zosyn) - other name: ceftolozane and tazobactam )
|
( piperacillin (pipracil), tazobactam (Zosyn) - other name: piperacillin and tazobactam )

Alternative names

ceftolozane sulfate / tazobactam sodium | cl-298741 | taszobactam sodium | tazobactam | tazobactam sodium | tazocel | ytr 830 | ytr-830 | ytr 830h | ytr-830h

Organizations (183)

Research & Development (166)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (23)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (75)

Approved Indications (5)


 

Intraabdominal Infections

Pelvic Infection (approved 1993)

Pneumonia (approved 1993)

Skin Diseases, Infectious (approved 1993)

Urinary Tract Infections

Experimental Indications - Clinical Trial Phases 1-4 (73)


 

Abdominal Abscess (Phase 3)

Abscess (Phase 3)

Acute Kidney Injury (Phase 4)

Appendicitis (Phase 4)

Asthma (Phase 4)

Bacteremia (Phase 4)

Bacterial Infections (Phase 4)

Bone Marrow Diseases (Phase 3)

Bronchiectasis (Phase 4)

Bronchitis (Phase 2/Phase 3)

Burkholderia Infections (Phase 4)

Burns (Phase 4)

Carbapenems (Phase 4)

Cerebrospinal Fluid Otorrhea (Phase 1/Phase 2)

Cholecystitis, Acute (Phase 3)

Clinical Trial (Phase 4)

Critical Illness (Phase 4)

Cross Infection (Phase 2)

Cystic Fibrosis (Phase 4)

Diabetes Mellitus (Phase 4)

Diabetic Foot (Phase 4)

Drug-Related Side Effects and Adverse Reactions (Phase 1)

Drug Resistance, Bacterial (Phase 4)

Drugs, Investigational (Phase 4)

Enterobacteriaceae Infections (Phase 4)

Escherichia coli Infections (Phase 4)

Febrile Neutropenia (Phase 4)

Fever (Phase 4)

Fractures, Open (Phase 4)

General Surgery (Phase 1)

Graft vs Host Disease (Phase 2)

Gram-Negative Bacteria (Phase 4)

Gram-Positive Bacterial Infections (Phase 4)

Healthcare-Associated Pneumonia (Phase 3)

Healthy Volunteers (Phase 1)

Hematologic Neoplasms (Phase 3)

Infections (Phase 4)

Intraabdominal Infections (Phase 3)

Kidney Failure, Chronic (Phase 1)

Klebsiella Infections (Phase 4)

Klebsiella pneumoniae (Phase 4)

Leukemia (Phase 3)

Liver Transplantation (Phase 3)

Lung Diseases (Phase 3)

Lymphoma (Phase 3)

Multiple Myeloma (Phase 3)

Myelodysplastic Syndromes (Phase 3)

Neonatal Sepsis (Phase 4)

Neoplasms (Phase 4)

Osteomyelitis (Phase 2)

Otitis Media (Phase 1/Phase 2)

Pancreatic Diseases (Phase 3)

Pancreatic Fistula (Phase 2)

Pancreatic Neoplasms (Phase 3)

Pancreaticoduodenectomy (Phase 3)

Pharmacokinetics (Phase 4)

Pneumonia (Phase 4)

Pneumonia, Bacterial (Phase 3)

Pneumonia, Ventilator-Associated (Phase 3)

Pseudomonas aeruginosa (Phase 4)

Pseudomonas Infections (Phase 4)

Pulmonary Disease, Chronic Obstructive (Phase 4)

Pyelonephritis (Phase 3)

Respiratory Tract Infections (Phase 4)

Sepsis (Phase 4)

Shock, Septic (Phase 4)

Stem Cell Transplantation (Phase 4)

Surgical Wound Infection (Phase 3)

Systemic Inflammatory Response Syndrome (Phase 2)

Ulcer (Phase 3)

Urinary Tract Infections (Phase 4)

Urination Disorders (Phase 4)

Wound Infection (Phase 4)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 113
  • # of Trial Organizations: 166

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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