pentazocine (talwin) Report issue

Small molecule Approved FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

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Pentazocine is a synthetically prepared prototypical mixed agonist-antagonist narcotic (opioid analgesic) drug of the benzomorphan class of opioids used to treat moderate to moderately severe pain. Pentazocine is sold under several brand names, such as Fortral, Sosegon, Talwin NX. Pentazocine acts as an agonist of κ-opioid receptors and as an antagonist of μ-opioid receptors. This compound may exist as one of two enantiomers, named (+)-pentazocine and (−)-pentazocine. Side effects are similar to those of morphine, but pentazocine, due to its action at the kappa opioid receptor is more likely to invoke psychotomimetic effects. High dose may cause high blood pressure or high heart rate.   NCATS

Chemistry

More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral, Parenteral
  • Pro Drug: No

Alternative names

cis-(+/-)-pentazocine | dl-pentazocine | fortral | pentazocin | pentazocina | pentazocine | pentazocine hcl | pentazocine hydrochloride | pentazocine lactate | pentazocinum | sosegon | talwin | win-20228

Organizations (16)

Research & Development (10)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (6)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (7)

Approved Indications (1)


 

Pain

Experimental Indications - Clinical Trial Phases 1-4 (7)


 

Abortion, Induced (Phase 4)

Anesthesia (Phase 4)

Bipolar Disorder (Phase 2)

Mania (Phase 2)

Menopause (Phase 1)

Pain (Phase 4)

Psychotic Disorders (Phase 2)

Overview

  • Highest Phase: Phase 4
  • # of Trials: 7
  • # of Trial Organizations: 10

Trials by Phase

Trial Phase Start Date Organizations Indications

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