Active Ingredient History
Retinoic acid (used simplified here for all-trans-retinoic acid) is a metabolite of vitamin A1 (all-trans-retinol) that mediates the functions of vitamin A1 required for growth and development. All-trans-retinoic acid is required in chordate animals, which includes all higher animals from fish to humans. During early embryonic development, all-trans-retinoic acid generated in a specific region of the embryo helps determine position along the embryonic anterior/posterior axis by serving as an intercellular signaling molecule that guides development of the posterior portion of the embryo. It acts through Hox genes, which ultimately control anterior/posterior patterning in early developmental stages. Wikipedia
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Alopecia (Early Phase 1)
Autistic Disorder (Early Phase 1)
Carcinoma, Squamous Cell (Phase 3)
Chromosomes (Early Phase 1)
Cosmetics ()
COVID-19 (Phase 4)
Emphysema (Phase 2)
Hypercholesterolemia (Early Phase 1)
Infertility, Male (Phase 2)
Leukemia, Myeloid, Acute (Phase 2)
Leukemia, Promyelocytic, Acute (Phase 3)
Lung Diseases (Phase 2)
Lung Diseases, Obstructive (Phase 2)
Melanoma (Phase 1/Phase 2)
Melanosis (Phase 4)
Mouth (Phase 3)
Myelodysplastic Syndromes (Phase 2)
Neoplasms (Phase 1)
Neuroblastoma (Phase 2)
Neuroendocrine Tumors (Phase 2)
Psoriasis (Phase 1)
Pulmonary Disease, Chronic Obstructive (Phase 2)
Treatment Adherence and Compliance (Early Phase 1)
Tretinoin (Early Phase 1)
Uterine Cervical Neoplasms (Phase 2)
Wilms Tumor (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
Feedback
Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).
Report issue