Active Ingredient History

NOW
  • Now
Pyrvinium (Viprynium) is an anthelmintic effective for pinworms. Pyrvinium is used in the treatment of enterobiasis caused by Enterobius vermicularis (pinworm). Pyrvinium has being shown to be a potent inhibitor of Wnt signaling (EC(50) of ∼10 nM). Pyrvinium binds all casein kinase 1 (CK1) family members in vitro at low nanomolar concentrations and pyrvinium selectively potentiates casein kinase 1α (CK1α) kinase activity. Pyrvinium pamoate (PP) is a potent noncompetitive inhibitor of the androgen receptor (AR). A noncompetitive AR inhibitor pyrvinium has significant potential to treat CRPC, including cancers driven by ligand-independent AR signaling.   NCATS

  • SMILES: CN(C)c1ccc2c(ccc(\C=C\c3cc(C)n(c3C)c4ccccc4)[n+]2C)c1
  • InChIKey: QMHSXPLYMTVAMK-UHFFFAOYSA-N
  • Mol. Mass: 382.53
  • ALogP: 5.31
  • ChEMBL Molecules:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Oral
  • Pro Drug: No
6-(dimethylamino)-2-(2-(2,5-dimethyl-1-phenyl-1h-pyrrol-3-yl)ethenyl)-1-methylquinolinium | molevac | pamoxan | poquil | povan | povanyl | pyrcon | pyrvinium | pyrvinium embonate | pyrvinium iodide | pyrvinium monohydroxide | pyrvinium pamoate | pyrvinium pamoate (2:1) | vankin | vanquil | vanquin | viprynium | viprynium embonate

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