API | thiothixene

thiothixene (navane) Report issue

Small molecule Approved ^FDA

AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW

THIOTHIXENE, (E)- (trans-thiothixene) )is a clinically inactive isomer of thiothixene. 1000 times higher concentration of this isomer than the active cis-isomer required to inhibit release of (3H) dopamine from rat striatal slices. Trans-thiothixene is about 50 times less potent than cis-thiothixene in inhibiting 3H-haloperidol binding at their binding sites in the rat brain. Cis-isomer of thiothixene is the active antipsychotic drug used in antipsychotic therapy. ^NCATS

Chemistry

SMILES: O.O.Cl.Cl.CN(C)S(=O)(=O)c1ccc2Sc3ccccc3\C(=C\CCN4CCN(C)CC4)\c2c1
InChIKey: MEUAAEMCZUPORO-LRSHZYOCSA-N
Mol. Mass: 552.59
ALogP: 3.47 Partition coefficient
ChEMBL Molecules:

thiothixene hydrochloride

thiothixene hydrochloride

thiothixene

More Chemistry

Pharmacology

Mechanisms of Action:
- D(2) dopamine receptor (Homo sapiens) ^UniProt
- 5-hydroxytryptamine receptor 2A (Homo sapiens) ^UniProt
Multi-specific: Missing data
Black Box: Yes
Availability: Discontinued
Delivery Methods: Oral, Parenteral
Pro Drug: No

Drug Pricing (per unit)

United States

$0.9400 - $2.6750

More Pricing Detail

Note: This drug pricing data is preliminary, incomplete, and may contain errors.

Organizations (15)

Research & Development (0)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Marketing (15)

Organization	Org Type	FDA approvals	Clinical Trials involvement	Org ID	Force Sort

Indications (1)

Approved Indications (1)

Schizophrenia (approved 1967)

Experimental Indications - Clinical Trial Phases 1-4 (0)

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