sodium mersalyl Report issue

Small molecule Withdrawn
ChEMBL DrugBank Drug Central KEGG MeSH PubChem

Active Ingredient History

NOW
  • Now
MERSALYL (Mersal) is an organomercury compound, mercurial diuretics that superseded by safer diuretics such as thiazides, and is hardly used anymore. Due to the idiosyncratic nature of mercury toxicity, the risk of severe disease and sudden death are unpredictable and frequently show no warning signs. Mercurial diuretics cause diuresis by reducing the reabsorption sodium in the ascending loop of Henle, thus causing more water being delivered to the distal convoluted tubule. Unfortunately, earlier physicians misconstrued hallmark symptoms of mercury poisoning such as excessive salivation as signs of mercury's efficacy, including up until the early 1960s when the use of mercurial diuretics was halted in medicine.   NCATS

Chemistry

  • SMILES: [OH-].[Na+].COC(C[Hg+])CNC(=O)C1=CC=CC=C1OCC([O-])=O
  • InChIKey: WWKZBHGJCDECFG-UHFFFAOYSA-L
  • Mol. Mass: 505.85
  • ALogP: Missing data
  • ChEMBL Molecules:
    mersalyl  
    mersalyl  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Parenteral
  • Pro Drug: No

Combination drugs

( theophylline (synophylate), sodium mersalyl )

Alternative names

mercuramide | mercurital | mercusal | mersal | mersalin | mersalyl | mersalyl acid sodium salt | mersalyl sodium | salyrgan | sodium mersalyl

Organizations (2)

Research & Development (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (2)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (1)

Approved Indications (1)


 

Hypertension

Experimental Indications - Clinical Trial Phases 1-4 (0)

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