diphenoxylate Report issue

Small molecule Approved FDA Priority Review FDA
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Diphenoxylate is an opioid drug used for the treatment of acute diarrhea. The drug is used in combination with atropine and marketed under names Lomotil and Diphenoxylate hydrochloride and atropine sulfate. Diphenoxylate is biotransformed in man by ester hydrolysis to diphenoxylic acid (difenoxine), which is biologically active and the major metabolite in the blood. The drug exerts its action by activating mu opioid receptors of intestinal mucosa.   NCATS

Chemistry

More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Prescription Only
  • Delivery Methods: Oral
  • Pro Drug: No

Combination drugs

( atropine, diphenoxylate - other names: colonai, di-atro, logen, lonox, lo-trol )

Alternative names

1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-isonipecotic acid ethyl ester | 2,2-diphenyl-4-(4-carbethoxy-4-phenylpiperidino)butyronitrile | 4-ethoxycarbonyl-alpha,alpha,4-triphenyl-1-piperidinebutyronitrile | 4-piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride, mixt. with endo-(+-)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl alpha-(hydroxymethyl)benzeneacetate sulfate (2:1) (salt) | atropine sulfate - diphenoxylate hydrochloride | atropine sulfate-diphenoxylate hydrochloride drug combination | difenossilato | difenoxilato | diphenoxylate | diphenoxylate hcl | diphenoxylate hydrochloride | diphenoxylatum | ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylate | ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotate | lomotil | reasec

Organizations (45)

Research & Development (3)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (42)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (3)

Approved Indications (1)


 

Diarrhea (approved 1960)

Experimental Indications - Clinical Trial Phases 1-4 (2)


 

Lymphoma (Phase 3)

Postoperative Nausea and Vomiting (Phase 3)

Overview

  • Highest Phase: Phase 3
  • # of Trials: 2
  • # of Trial Organizations: 3

Trials by Phase

Trial Phase Start Date Organizations Indications

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