cyclomandol Report issue

Small molecule Experimental
ChEMBL DrugBank Drug Central KEGG MeSH PubChem

Active Ingredient History

Cyclandelate is a vasodilator developed for the treatment of cardiovascular diseases. The drug was used in many countries for such diseases as intermittent claudication, arteriosclerosis obliterans, thrombophlebitis, nocturnal leg cramps, local frostbite, Raynaud's phenomenon. In the USA it was also approved for intermittent claudication and cognitive dysfunction in Alzheimer's disease under the name Cyclospasmol. Cyclandelate exerts its effect by blocking calcium channels and inhibiting smooth muscles contration. Cyclandelate was withdrawn from the market in the USA for lack of effectiveness.   NCATS

Chemistry

  • SMILES: CC1CC(CC(C)(C)C1)OC(=O)C(O)C2=CC=CC=C2
  • InChIKey: WZHCOOQXZCIUNC-UHFFFAOYSA-N
  • Mol. Mass: 276.3707
  • ALogP: 3.48
  • ChEMBL Molecule:
    cyclandelate  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

3,3,5-trimethylcyclohexyl mandelate | 3,5,5-trimethylcyclohexyl amygdalate | ciclandelato | cyclandelate | cyclandelatum | cyclergine | cyclobral | cyclolyt | cyclomandol | cyclospasmol

Indications (2)

Approved Indications (2)


 

Alzheimer Disease

Intermittent Claudication

Experimental Indications - Clinical Trial Phases 1-4 (0)

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