propiolattone Report issue

Small molecule Approved FDA
ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem

Active Ingredient History

NOW
  • Now
Propiolactone (or beta-propiolactone) is a disinfectant used in vapor form to sterilize vaccines, grafts, blood plasma, surgical instruments. It has been used against bacteria, fungi, and virus. Propiolactone was first commercially available in the United States in 1958 but then was withdrawn because it was discovered that compound was a human carcinogen. The results have shown the generation of tumors in several tissues and from different administration routes. Propiolactone is a direct-acting alkylating agent that reacts with polynucleotides and DNA, mainly at N7 of guanine and N1 of adenine, to form carboxyethyl derivatives.   NCATS

Chemistry

  • SMILES: O=C1CCO1
  • InChIKey: VEZXCJBBBCKRPI-UHFFFAOYSA-N
  • Mol. Mass: 72.0627
  • ALogP: -0.07
  • ChEMBL Molecule:
    propiolactone  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

1,3-propiolactone | 2-oxetanone | betaprone | beta-propiolactone | hydracrylic acid beta-lactone | propanolide | propiolactone | propiolattone | β-propiolactone

Organizations (1)

Research & Development (0)

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Marketing (1)

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Indications (1)

Approved Indications (1)


 

Bacterial Infections (approved 1958)

Experimental Indications - Clinical Trial Phases 1-4 (0)

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