Active Ingredient History
Furosemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome. Furosemide inhibits water reabsorption in the nephron by blocking the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle. This is achieved through competitive inhibition at the chloride binding site on the cotransporter, thus preventing the transport of sodium from the lumen of the loop of Henle into the basolateral interstitium. Consequently, the lumen becomes more hypertonic while the interstitium becomes less hypertonic, which in turn diminishes the osmotic gradient for water reabsorption throughout the nephron. Because the thick ascending limb is responsible for 25% of sodium reabsorption in the nephron, furosemide is a very potent diuretic. Furosemide is sold under the brand name Lasix among others. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Acute Kidney Injury (Phase 4)
Acute Lung Injury (Phase 2)
Anemia, Sickle Cell (Phase 1)
Ascites (Phase 4)
Atherosclerosis (Phase 4)
Biomarkers (Early Phase 1)
Body Fluids (Phase 4)
Body Weight Changes (Phase 1)
Brain Neoplasms (Phase 3)
Bronchiolitis (Phase 3)
Bronchopulmonary Dysplasia (Phase 4)
Carcinoma (Phase 2)
Carcinoma, Hepatocellular (Phase 3)
Cardiomyopathies (Phase 1)
Cardio-Renal Syndrome (Phase 2)
Congenital Hyperinsulinism (Phase 3)
COVID-19 (Phase 2/Phase 3)
Critical Illness (Phase 4)
Cystoscopy (Phase 4)
Delayed Graft Function (Phase 2)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 2 (Phase 4)
Diabetic Nephropathies (Phase 4)
Diuresis (Phase 4)
Drug Interactions (Phase 1)
Dyspnea (Phase 1/Phase 2)
Edema (Phase 4)
Essential Hypertension (Phase 3)
Fibrosis (Phase 4)
Healthy Volunteers (Phase 4)
Heart Diseases (Phase 4)
Heart Failure, Diastolic (Phase 4)
Hematuria (Phase 3)
Hemodialysis, Home (Phase 4)
Hemodynamics (Phase 1)
Hodgkin Disease (Phase 1/Phase 2)
Hypertension ()
Hypertension, Pregnancy-Induced (Phase 4)
Hypotension (Phase 4)
Infant, Premature (Early Phase 1)
Inflammation (Phase 1/Phase 2)
Intestinal Diseases (Phase 4)
Keratosis, Actinic (Phase 2)
Kidney Calculi (Phase 3)
Kidney Diseases (Phase 3)
Kidney Failure, Chronic (Phase 4)
Leukemia (Phase 1/Phase 2)
Leukemia, Myeloid, Acute (Phase 1/Phase 2)
Lewy Body Disease (Phase 3)
Liver Cirrhosis (Phase 4)
Lung Diseases (Phase 3)
Lymphoma, Non-Hodgkin (Phase 1/Phase 2)
Malabsorption Syndromes (Phase 1)
Melanoma (Phase 1)
Multiple Myeloma (Phase 1/Phase 2)
Myelodysplastic Syndromes (Phase 1/Phase 2)
Myocardial Infarction (Phase 3)
Nasal Polyps (Phase 2)
Neonatology (Phase 2)
Neoplasms (Phase 2)
Nephrolithiasis (Phase 3)
Nephrotic Syndrome (Phase 4)
Neuroblastoma (Phase 3)
Neuroendocrine Tumors (Phase 3)
Non-alcoholic Fatty Liver Disease (Phase 2)
Ovarian Torsion (Early Phase 1)
Parkinson Disease (Phase 3)
Pharmacokinetics (Phase 1)
Pharmacology (Phase 4)
Pre-Eclampsia (Phase 4)
Pregnancy Complications (Phase 3)
Premature Birth (Early Phase 1)
Prostatic Hyperplasia (Phase 3)
Prostatic Neoplasms (Phase 2)
Proteinuria (Phase 4)
Pulmonary Disease, Chronic Obstructive (Phase 3)
Pulmonary Edema (Phase 4)
Pulmonary Embolism (Phase 4)
Renal Insufficiency (Phase 3)
Renal Insufficiency, Chronic (Phase 4)
Respiratory Insufficiency (Phase 2/Phase 3)
Salts (Phase 1/Phase 2)
Schizophrenia (Phase 1)
Sodium (Phase 3)
Stomach Diseases (Phase 1)
Transfusion Reaction (Early Phase 1)
Transient Tachypnea of the Newborn (Phase 3)
Ureterolithiasis (Phase 3)
Urinary Calculi (Phase 3)
Urolithiasis (Phase 3)
Warts (Phase 3)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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