Active Ingredient History
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. Tetracaine blocks sodium ion channels required for the initiation and conduction of neuronal impulses thereby affecting local anesthesia. In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely. NCATS
Combination drugs
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Anesthetics, Local (approved 2006)
Abscess (Early Phase 1)
Acne Vulgaris (Phase 4)
Anesthesia (Phase 4)
Anesthesia, Dental (Phase 4)
Anesthesia, Local (Phase 4)
Anesthetics, Local (Phase 2)
Anxiety (Phase 4)
Behavior (Phase 4)
Carpal Tunnel Syndrome (Phase 2)
Cataract (Phase 3)
Catheters (Phase 4)
Cognition Disorders (Phase 4)
Corneal Injuries (Phase 3)
Dental Caries (Phase 2)
Dental Pulp Diseases (Phase 4)
Dermatology (Phase 4)
Elbow (Phase 4)
Endodontics (Phase 4)
Healthy Volunteers (Phase 4)
Hearing Loss, Sensorineural (Early Phase 1)
Infant, Newborn (Phase 3)
Lacerations (Phase 4)
Linear Energy Transfer (Phase 4)
Meniere Disease (Early Phase 1)
Multiple Sclerosis (Phase 4)
Myofascial Pain Syndromes (Phase 2)
Nasolabial Fold (Phase 4)
Neuralgia, Postherpetic (Phase 2)
Osteoarthritis, Knee (Phase 1/Phase 2)
Pain ()
Pain, Procedural (Phase 4)
Periapical Periodontitis (Phase 2)
Phlebotomy (Phase 2)
Pulpitis (Phase 4)
Pupil Disorders (Phase 2)
Shoulder Impingement Syndrome (Phase 2)
Shoulder Pain (Phase 2)
Steroids (Early Phase 1)
Tattooing (Phase 4)
Tendinopathy (Phase 2)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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