Active Ingredient History

  • Now
Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo1 and hand eczema.2 After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death unless repaired by cellular mechanisms. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.3 The compound is also being explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair.Trioxsalen was discontinued by the manufacturer in December 2002.   NCATS

  • SMILES: CC1=CC2=CC3=C(OC(=O)C=C3C)C(C)=C2O1
  • Mol. Mass: 228.2433
  • ALogP: 3.46
  • ChEMBL Molecule:
More Chemistry
  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Discontinued
  • Delivery Methods: Oral
  • Pro Drug: No
2',4,8-trimethylpsoralen | 4,5',8-trimethylpsoralen | 4,8,5'-trimethylpsoralen | 6-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone | trimethylpsoralen | trioxisaleno | trioxsalen | trioxysalen | trioxysalene | trioxysalenum | trisoralen


Data collection and curation is an ongoing process for CDEK - if you notice any information here to be missing or incorrect, please let us know! When possible, please include a source URL (we verify all data prior to inclusion).

Report issue