tolmetin (tolectin) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

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Tolmetin is a nonsteroidal anti-inflammatory agent. It was marketed as Tolectin in USA. TOLECTIN (tolmetin sodium) is indicated for the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. TOLECTIN is indicated in the treatment of acute flares and the long-term management of the chronic disease. TOLECTIN is also indicated for treatment of juvenile rheumatoid arthritis. The mode of action of tolmetin is not known. However, studies in laboratory animals and man have demonstrated that the anti-inflammatory action of tolmetin is not due to pituitary-adrenal stimulation. Tolmetin inhibits prostaglandin synthetase in vitro and lowers the plasma level of prostaglandin E in man. This reduction in prostaglandin synthesis may be responsible for the anti-inflammatory action.   NCATS

Chemistry

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Pharmacology

Alternative names

1-methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid | 1-methyl-5-p-toluoylpyrrole-2-acetic acid | 5-(p-toluoyl)-1-methylpyrrole-2-acetic acid | amtolmetineguacil | amtolmetin guacil | amtolmetin guacyl | artromed | mcn-2559 | mcn-2559-21-98 | st-679 | tolectin | tolectin 600 | tolectin ds | tolmetin | tolmetina | tolmetine | tolmétine | tolmetino | tolmetin sodium | tolmetin sodium anhydrous | tolmetin sodium salt | tolmetin sodium salt dihydrate | tolmetinum

Organizations (11)

Research & Development (0)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (11)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (3)

Approved Indications (2)


 

Arthritis, Rheumatoid (approved 1976)

Osteoarthritis (approved 1976)

Experimental Indications - Clinical Trial Phases 1-4 (1)


 

Osteoarthritis, Knee (Phase 4)

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