sulfameter (sulla) Report issue

Small molecule Approved FDA
ChEMBL Drug Central Drugs@FDA KEGG MeSH PubChem

Active Ingredient History

NOW
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Sulfametoxydiazine (INN) or sulfamethoxydiazine (USAN: sulfameter) is a long-acting sulfonamide antibacterial, shows bacteriostatic effects against Gram positive and Gram negative bacteria in vivo. It is used as a leprostatic agent and in the treatment of urinary tract infections. Orally active. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfameter is a dihydrofolate reductase (DHFR) inhibitor. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.   NCATS

Chemistry

  • SMILES: COC1=CN=C(NS(=O)(=O)C2=CC=C(N)C=C2)N=C1
  • InChIKey: GPTONYMQFTZPKC-UHFFFAOYSA-N
  • Mol. Mass: 280.303
  • ALogP: 0.87
  • ChEMBL Molecule:
    sulfameter  
More Chemistry

Pharmacology

Alternative names

ahr-857 | bayrena | methoxypyrimal | sulfameter | sulfamethoxine | sulfamethoxydiazine | sulfamethoxydin | sulfamethoxypyrimidine | sulfametin | sulfametorine | sulfametoxydiazine | sulla | sulphamethoxydiazine | ultrax

Organizations (1)

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Indications (1)

Approved Indications (1)


 

Urinary Tract Infections (approved 1966)

Experimental Indications - Clinical Trial Phases 1-4 (0)

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