nitrofural Report issue

Small molecule Approved FDA
ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Nitrofurazone is used to treat burns that have become infected. It is also used to treat skin infections due to skin grafts. It works by killing bacteria or preventing their growth. The exact mechanism of action is unknown. Nitrofurazone inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. The severe or irreversible adverse effects of Nitrofurazone, which give rise to further complications include Peripheral neuropathy, Thromboembolic disorder.   NCATS

Chemistry

  • SMILES: NC(=O)N\N=C\C1=CC=C(O1)[N+]([O-])=O
  • InChIKey: IAIWVQXQOWNYOU-FPYGCLRLSA-N
  • Mol. Mass: 198.1362
  • ALogP: 0.6
  • ChEMBL Molecule:
    nitrofurazone  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Topical
  • Pro Drug: Yes

Alternative names

5-nitro-2-furaldehyde semicarbazone | actin-n | aldomycin | babrocid | furacilin | furacin | furacine | furacycline | furaldon | furaziline | furazone | nifuzon | nitrofural | nitrofuraldehyde semicarbazone | nitrofuran | nitrofurazone | nitrozone

Organizations (10)

Research & Development (2)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (8)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (3)

Approved Indications (2)


 

Burns (approved 1945)

Skin Diseases, Bacterial (approved 1945)

Experimental Indications - Clinical Trial Phases 1-4 (1)


 

Amyotrophic Lateral Sclerosis (Phase 2)

Overview

  • Highest Phase: Phase 2
  • # of Trials: 1
  • # of Trial Organizations: 2

Trials by Phase

Trial Phase Start Date Organizations Indications

Feedback

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