cephaloglycin (kafocin) Report issue

Small molecule Approved FDA
ChEMBL DrugBank Drug Central Drugs@FDA KEGG MeSH PubChem

Active Ingredient History

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Cephaloglycin, first oral cephalosporin, was introduced in 1965, but is no longer in common use. It is an orally absorbed derivative of cephalosporin C. Cephaloglycin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.   NCATS

Chemistry

  • SMILES: CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)C3=CC=CC=C3)C2=O)C(O)=O
  • InChIKey: FUBBGQLTSCSAON-PBFPGSCMSA-N
  • Mol. Mass: 405.425
  • ALogP: -0.01
  • ChEMBL Molecule:
    cephaloglycin  
More Chemistry

Pharmacology

Alternative names

39435 | 7-(2-d-alpha-aminophenylacetamido)cephalosporanic acid | 7-(d-2-amino-2-phenylacetamido)-3-acetoxymethyl-delta(sup3)-cephem-4-carboxylic acid | 7-(d-alpha-aminophenyl-acetamido)cephalosporanic acid | cefaloglicina | cefaloglycin | cefaloglycine | cefaloglycinum | ceg | cephaloglycin | cephaloglycine | cephaoglycin acid | d-(-)-cephaloglycin | d-cephaloglycine | kafocin | kefglycin

Organizations (1)

Research & Development (0)

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Indications (1)

Approved Indications (1)


 

Bacterial Infections (approved 1970)

Experimental Indications - Clinical Trial Phases 1-4 (0)

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