progestoral Report issue

Small molecule Experimental
ChEMBL Drug Central MeSH PubChem

Active Ingredient History

Ethisterone is a metabolite of danazol. Ethisterone is a progestogen hormone. The first orally active progestin, Ethisterone (brand names Pranone, Progestoral, Lutocylol, Proluton C), also known as 17α-ethinyltestosterone, pregneninolone, or anhydrohydroxyprogesterone, is a steroidal progestin with androgenic activity which is derived from testosterone and was introduced for medical use in 1939. Ethisterone is indicated for progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used as a female contraceptive.   NCATS

Chemistry

  • SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@]2(O)C#C
  • InChIKey: CHNXZKVNWQUJIB-CEGNMAFCSA-N
  • Mol. Mass: 312.4458
  • ALogP: 4.93
  • ChEMBL Molecules:
    pregnenolone succinate  
    ethisterone  
More Chemistry

Pharmacology

Alternative names

aethisteron | anhydrohydroxyprogesterone | anhydroxyprogesterone | ethinone | ethinyltestosterone | ethisterone | ethynyltestosterone | formula 405 | nugestoral | ora-lutin | pranone | pregneninolone | progestoral | syngestrotabs | trosinone

Indications (3)

Approved Indications (3)


 

Amenorrhea

Endometriosis

Infertility, Female

Experimental Indications - Clinical Trial Phases 1-4 (0)

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