barbital (Veronal) Report issue

Small molecule Experimental
ChEMBL DrugBank Drug Central KEGG MeSH PubChem

Active Ingredient History

Barbital, the one of the series of barbiturates, has hypnotic, sedative, and anticonvulsant properties and used under the trade name Veronal. It calmed manic patients and helped melancholic patients to sleep and was an effective inducer of sleep in insomniacs, but at the same time compound could induced dependence. It was substituted by the butyl analog, butobarbital, which was three times stronger and its period of action was much shorter due to its lipophilicity. Barbital is a ligand of GABA-receptor complex and in addition, it could have another target, a creatine kinase.   NCATS

Chemistry

  • SMILES: CCC1(CC)C(=O)NC(=O)NC1=O
  • InChIKey: FTOAOBMCPZCFFF-UHFFFAOYSA-N
  • Mol. Mass: 184.19
  • ALogP: 0.16
  • ChEMBL Molecules:
    barbital  
    barbital sodium  
More Chemistry

Pharmacology

  • Mechanisms of Action:
  • Multi-specific: Missing data
  • Black Box: No
  • Availability: Missing data
  • Delivery Methods: Missing data
  • Pro Drug: No

Alternative names

barbital | barbital sodium | barbital, soluble | barbitone | barbitone sodium | diemal | diethylbarbitone | diethylbarbituric acid | diethylmalonylurea | ethylbarbital | sodium diethylbarbiturate | veronal

Indications (1)

Approved Indications (1)


 

Sleep Initiation and Maintenance Disorders

Experimental Indications - Clinical Trial Phases 1-4 (0)

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