vilanterol (Anoro Elipta) Report issue

Small molecule Approved FDA
AACT ChEMBL DrugBank Drug Central KEGG MeSH PubChem repoDB

Active Ingredient History

NOW
  • Now
Vilanterol (INN, USAN) is an ultra-long-acting β2 adrenoreceptor agonist (ultra-LABA), which was approved in May 2013 in combination with fluticasone furoate for sale as Breo Ellipta by GlaxoSmithKline for the treatment of chronic obstructive pulmonary disease (COPD). Its pharmacological effect is attributable to stimulation of intracellular adenylyl cyclase which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3’,5’-adenosine monophosphate (cAMP). Increases in cyclic AMP are associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs. Vilanterol is available in following combinations: a) with inhaled corticosteroid fluticasone furoate — fluticasone furoate/vilanterol (trade names Breo Ellipta , Relvar Ellipta; b) with muscarinic antagonist umeclidinium bromide — umeclidinium bromide/vilanterol (trade name Anoro Ellipta).   NCATS

Chemistry

  • SMILES: OCc1cc(ccc1O)[C@@H](O)CNCCCCCCOCCOCc2c(Cl)cccc2Cl
  • InChIKey: DAFYYTQWSAWIGS-DEOSSOPVSA-N
  • Mol. Mass: 486.44
  • ALogP: 4.61
  • ChEMBL Molecules:
    vilanterol  
    vilanterol trifenatate  
More Chemistry

Pharmacology

  • Mechanism of Action:
  • Multi-specific: Missing data
  • Black Box: Yes
  • Availability: Prescription Only
  • Delivery Methods: Topical
  • Pro Drug: No

Combination drugs

( umeclidinium (incruse ellipta), vilanterol (Anoro Elipta) )
|
( fluticasone (cutivate), vilanterol (Anoro Elipta) - other name: fluticasone furoate / vilanterol trifenatate 100/25 mcg )
|
( fluticasone (cutivate), umeclidinium (incruse ellipta), vilanterol (Anoro Elipta) )

Alternative names

4-{(1r)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol | 4-(2-((6-((2-(((2,6-dichlorophenyl)methyl)oxy)ethyl)oxy)hexyl)amino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol | breo ellipta | fluticasone furoate / umeclidinium bromide / vilanterol trifenatate | fluticasone furoate, umeclidinium bromide, vilanterol trifenatate | fluticasone furoate / vilanterol | fluticasone furoate / vilanterol trifenatate | gw6422444 | gw642444 | gw642444m | gw642444x | umeclidinium bromide / vilanterol | umeclidinium bromide / vilanterol trifenatate | vilanterol | vilantérol | vilanterol trifenatate

Organizations (31)

Research & Development (31)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Marketing (1)

Organization Org Type FDA approvals Clinical Trials involvement Org ID Force Sort

Indications (7)

Approved Indications (4)


 

Asthma

Bronchitis, Chronic

Emphysema

Pulmonary Disease, Chronic Obstructive

Experimental Indications - Clinical Trial Phases 1-4 (5)


 

Asthma ()

Carcinoma, Non-Small-Cell Lung (Phase 3)

Heart Failure (Phase 4)

Pharmacokinetics (Phase 2)

Pulmonary Disease, Chronic Obstructive ()

Overview

  • Highest Phase: Phase 4
  • # of Trials: 143
  • # of Trial Organizations: 31

Trials by Phase

Trial Phase Start Date Organizations Indications

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