sacubitril (Entresto) Report issue

Small molecule Approved FDA First in Class Fast Track FDA Priority Review FDA

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Chemistry

Mol. Mass

383.4376

ALogP

3.84

Rule of 5

Yes

Rule of 3

No
Details
  • SMILES: C[C@H](C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(O)=O)C(O)=O
  • InChIKey: DOBNVUFHFMVMDB-BEFAXECRSA-N
    1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19+/m1/s1
  • Chirality: Single Stereoisomer
  • Inorganic: No
  • Polymer: No

Sources

CHEMBL3137301   ChEMBL
sacubitril

SPI5PBF81S   NCATS
sacubitrilat *

Sacubitril   Wikipedia

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