Active Ingredient History
Clopidogrel, an antiplatelet agent structurally and pharmacologically similar to ticlopidine, is used to inhibit blood clots in a variety of conditions such as peripheral vascular disease, coronary artery disease, and cerebrovascular disease. Clopidogrel is sold under the name Plavix by Sanofi and Bristol-Myers Squibb. Plavix (clopidogrel bisulfate) is an inhibitor of ADP-induced platelet aggregation acting by direct inhibition of adenosine diphosphate (ADP) binding to its receptor and of the subsequent ADPmediated activation of the glycoprotein GPIIb/IIIa complex. Clopidogrel must be metabolized by CYP450 enzymes to produce the active metabolite that inhibits platelet aggregation. The active metabolite of clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADPmediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. This action is irreversible. Consequently, platelets exposed to clopidogrel’s active metabolite are affected for the remainder of their lifespan (about 7 to 10 days). Platelet aggregation induced by agonists other than ADP is also inhibited by blocking the amplification of platelet activation by released ADP. Plavix (clopidogrel bisulfate) is indicated for the reduction of atherothrombotic events. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
| Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
|---|
Atherosclerosis (approved 1997)
Abortion, Habitual (Phase 2/Phase 3)
Accidents (Phase 4)
Acute Coronary Syndrome (Phase 4)
Adenosine (Phase 2)
Aneurysm (Phase 4)
Angina Pectoris (Phase 4)
Angina, Stable (Phase 4)
Angina, Unstable (Phase 4)
Angioplasty (Phase 4)
Angioplasty, Balloon, Coronary (Phase 4)
Ankle Injuries (Phase 4)
Anticoagulants (Phase 4)
Anti-Inflammatory Agents (Phase 4)
Antiphospholipid Syndrome (Phase 4)
Antithrombins (Phase 4)
Aorta (Phase 1)
Aortic Stenosis, Subvalvular (Phase 4)
Aortic Valve Disease (Phase 4)
Aortic Valve Stenosis (Phase 4)
Appendix (Phase 4)
Arterial Occlusive Diseases (Phase 4)
Arteriosclerosis (Phase 4)
Aspirin (Phase 4)
Asthma (Phase 2)
Atherosclerosis (Phase 4)
Atrial Appendage (Phase 4)
Atrial Fibrillation (Phase 4)
Atrophic Vaginitis (Phase 1/Phase 2)
Blood Platelet Disorders (Phase 4)
Blood Platelets (Phase 4)
Blood Pressure (Phase 4)
Brain Infarction (Phase 3)
Breast Neoplasms (Phase 2)
Cardiovascular Diseases (Phase 4)
Carotid Artery Diseases (Phase 3)
Carotid Stenosis (Phase 4)
Cerebral Hemorrhage (Phase 3)
Cerebral Infarction (Phase 4)
Cerebrovascular Disorders (Phase 4)
Cervix Uteri (Phase 3)
Chest Pain (Phase 4)
Chronic Limb-Threatening Ischemia (Phase 4)
Clopidogrel (Phase 2)
Cognition Disorders (Phase 1/Phase 2)
Constriction, Pathologic (Phase 4)
Coronary Aneurysm (Phase 3)
Coronary Artery Bypass (Phase 4)
Coronary Artery Disease (Phase 4)
Coronary Disease (Phase 4)
Coronary Restenosis (Phase 4)
Coronary Stenosis (Phase 4)
Coronavirus Infections (Phase 2)
COVID-19 (Phase 4)
Critical Illness (Phase 2)
Cytochrome P-450 CYP2C19 (Phase 2)
Depressive Disorder, Major (Phase 1)
Diabetes Mellitus (Phase 4)
Diabetes Mellitus, Type 2 (Phase 4)
Diabetic Nephropathies (Phase 4)
Diabetic Retinopathy (Phase 2)
Disease Susceptibility (Phase 2)
Drug-Eluting Stents (Phase 4)
Drug Interactions (Phase 4)
Drugs, Investigational (Phase 4)
Dual Anti-Platelet Therapy (Phase 4)
Embolic Stroke (Phase 4)
Embolism (Phase 4)
Embolism and Thrombosis (Phase 2)
Embolism, Paradoxical (Phase 4)
Endomyocardial Fibrosis (Phase 4)
Endothelial Cells (Phase 4)
Endothelium (Phase 4)
Endovascular Procedures (Phase 4)
Fasting (Phase 1)
Fibrinolysis (Phase 4)
Fibrinolytic Agents (Phase 3)
Foramen Ovale, Patent (Phase 4)
Fractional Flow Reserve, Myocardial (Phase 4)
General Surgery (Phase 3)
Head and Neck Neoplasms (Phase 2)
Healthy Volunteers (Phase 4)
Heart (Phase 4)
Heart Arrest (Phase 4)
Heart Defects, Congenital (Phase 3)
Heart Diseases (Phase 4)
Heart Failure (Phase 3)
Heart Failure, Systolic (Phase 4)
Heart Septal Defects, Atrial (Phase 4)
Heart Transplantation (Phase 3)
Heart Valve Diseases (Phase 3)
Hemodialysis, Home (Phase 3)
Hemorrhage (Phase 4)
Hemostasis (Phase 1)
HIV (Phase 2)
HIV Infections (Phase 2)
Hypercholesterolemia (Phase 1)
Hyperlipidemias (Phase 1)
Hypertension (Phase 4)
Hypertension, Pulmonary (Phase 2)
Hypertrophy, Left Ventricular (Phase 4)
Infarction (Phase 4)
Infarction, Middle Cerebral Artery (Phase 3)
Infertility, Female (Phase 4)
Inflammation (Phase 4)
Intermittent Claudication (Phase 4)
Intestinal Neoplasms (Phase 4)
Intracranial Aneurysm (Phase 4)
Intracranial Arteriosclerosis (Phase 3)
Intracranial Embolism (Phase 3)
Ischemia (Phase 4)
Ischemic Attack, Transient (Phase 4)
Ischemic Stroke (Phase 4)
Kidney Diseases (Phase 4)
Kidney Failure, Chronic (Phase 4)
Lipoproteins (Phase 1)
Livedoid Vasculopathy (Phase 3)
Lupus Erythematosus, Systemic (Phase 1/Phase 2)
Macular Degeneration (Phase 3)
Medicine, Chinese Traditional (Phase 4)
Metabolic Syndrome (Phase 4)
Metabolism (Phase 4)
Migraine Disorders (Phase 4)
MINOCA (Phase 4)
Mucocutaneous Lymph Node Syndrome (Phase 3)
Myocardial Ischemia (Phase 4)
Myocardial Reperfusion Injury (Phase 4)
Myocardial Stunning (Phase 4)
Neoplasms (Phase 4)
Non-ST Elevated Myocardial Infarction (Phase 4)
No-Reflow Phenomenon (Phase 4)
Overweight (Phase 4)
Pancreatic Neoplasms (Phase 3)
Peptic Ulcer (Phase 4)
Percutaneous Coronary Intervention (Phase 4)
Peripheral Arterial Disease (Phase 4)
Peripheral Vascular Diseases (Phase 4)
Pharmacokinetics (Phase 4)
Pharmacology (Phase 4)
Plaque, Atherosclerotic (Phase 4)
Platelet Aggregation (Phase 4)
Platelet Aggregation Inhibitors (Phase 4)
Pneumonia, Viral (Phase 2)
Polycythemia Vera (Phase 2)
Post-Cardiac Arrest Syndrome (Phase 4)
Prostheses and Implants (Phase 3)
Pulmonary Disease, Chronic Obstructive (Phase 3)
Renal Dialysis (Phase 3)
Renal Insufficiency (Phase 3)
Renal Insufficiency, Chronic (Phase 4)
Respiratory Insufficiency (Phase 2)
Rivaroxaban (Phase 4)
Scleroderma, Systemic (Phase 2/Phase 3)
ST Elevation Myocardial Infarction (Phase 4)
Stents (Phase 4)
Stomach Neoplasms (Phase 4)
Stomatognathic Diseases (Phase 4)
Stroke (Phase 4)
Therapeutic Equivalency (Phase 1)
Thromboembolism (Phase 2)
Thrombophilia (Phase 3)
Thrombosis (Phase 4)
Ticagrelor (Phase 4)
Transcatheter Aortic Valve Replacement (Phase 4)
Vascular Diseases (Phase 4)
Vascular Grafting (Phase 4)
Venous Thromboembolism (Phase 4)
Ventricular Outflow Obstruction (Phase 3)
Vertebral Artery Dissection (Phase 3)
Warfarin (Phase 3)
| Trial | Phase | Start Date | Organizations | Indications |
|---|
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