Active Ingredient History
Dactinomycin (actinomycin D) was isolated from Streptomyces by Selman Waksman in 1940s. The antibiotic shows anti-cancer activity; it was approved by FDA for the treatment of different cancer conditions among which are Ewing's sarcoma, Wilm's tumor, gestational trophoblastic disease, etc. Dactinomycin exerts its action by binding to DNA (preferably to GC motif) and thus inhibiting transcription. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Adenocarcinoma (approved 1964)
Carcinoma (approved 1964)
Gestational Trophoblastic Disease (approved 1964)
Rhabdomyosarcoma (approved 1964)
Sarcoma (approved 1964)
Sarcoma, Ewing (approved 1964)
Testicular Neoplasms (approved 1964)
Wilms Tumor (approved 1964)
Beckwith-Wiedemann Syndrome (Phase 3)
Brain Neoplasms (Phase 3)
Carcinoma, Renal Cell (Phase 2)
Choriocarcinoma (Phase 3)
Choroid Plexus Neoplasms (Phase 3)
Drug-Related Side Effects and Adverse Reactions (Phase 2/Phase 3)
Fibrosarcoma (Phase 2)
Gestational Trophoblastic Disease (Phase 3)
Hydatidiform Mole (Phase 3)
Hypertrophy (Phase 3)
Intestinal Neoplasms (Phase 2)
Kidney Diseases (Phase 3)
Kidney Neoplasms (Phase 3)
Leukemia (Phase 3)
Lymphoma (Phase 3)
Melanoma (Phase 2)
Neoplasm Metastasis (Phase 3)
Neoplasms (Phase 4)
Neoplasms, Germ Cell and Embryonal (Phase 2)
Ovarian Neoplasms (Phase 2)
Rhabdomyosarcoma (Phase 3)
Rhabdomyosarcoma, Alveolar (Phase 3)
Rhabdomyosarcoma, Embryonal (Phase 3)
Sarcoma (Phase 3)
Sarcoma, Alveolar Soft Part (Phase 2)
Sarcoma, Ewing (Phase 3)
Uterine Cervical Neoplasms (Phase 2)
Uterine Neoplasms (Phase 3)
Wilms Tumor (Phase 3)
Trial | Phase | Start Date | Organizations | Indications |
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