Active Ingredient History
Regadenoson (Lexiscan), a low affinity agonist of the A2A adenosine receptor, increases coronary blood flow (CBF) and mimics the increase in CBF caused by exercise. Myocardial uptake of the radiopharmaceutical is proportional to CBF creating the contrast required to identify stenotic coronary arteries. It is a pharmacologic stress agent indicated for radionuclide myocardial perfusion imaging (MPI) in patients unable to undergo adequate exercise stress. The most common adverse reactions to Lexiscan are dyspnea, headache, flushing, chest discomfort, dizziness, angina pectoris, chest pain, and nausea. Methylxanthines, e.g., caffeine and theophylline, may interfere with the activity of Lexiscan. Aminophylline may be used to attenuate severe and/or persistent adverse reactions to Lexiscan. NCATS
Drug Pricing (per unit)
Note: This drug pricing data is preliminary, incomplete, and may contain errors.
Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Organization | Org Type | FDA approvals | Clinical Trials involvement | Org ID | Force Sort |
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Myocardial Perfusion Imaging (approved 2008)
Anemia, Sickle Cell (Phase 2)
Angina Pectoris (Phase 4)
Asthma (Phase 4)
Atrial Fibrillation (Phase 2)
Brain Diseases (Early Phase 1)
Cardiomyopathies (Phase 4)
Cardiomyopathy, Hypertrophic (Phase 4)
Cardiovascular Diseases (Phase 2)
Coronary Artery Disease (Phase 4)
COVID-19 (Phase 1/Phase 2)
Diabetes Mellitus, Type 1 (Phase 4)
Graft Rejection (Phase 4)
Healthy Volunteers (Phase 1)
Heart Diseases (Phase 2)
Heart Failure (Phase 4)
Heart Failure, Diastolic (Phase 4)
Heart Transplantation (Phase 4)
Hypertension (Phase 4)
Ischemia (Phase 4)
Kidney Diseases (Phase 4)
Lung Transplantation (Phase 1)
Magnetic Resonance Imaging (Early Phase 1)
Myocardial Ischemia (Phase 4)
Myocardium (Phase 4)
Pneumonia (Phase 1/Phase 2)
Pulmonary Disease, Chronic Obstructive (Phase 4)
Retinal Artery Occlusion (Phase 2)
Trial | Phase | Start Date | Organizations | Indications |
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